Effect of bisphosphonates on bone architecture and glucose metabolism in men with prostate cancer receiving androgen deprivation therapy: a randomised controlled trial

双膦酸盐对接受雄激素剥夺治疗的前列腺癌男性骨结构和葡萄糖代谢的影响：一项随机对照试验

• 批准号: nhmrc : 1062073
• 负责人: Prof Jeffrey Zajac
• 金额: $ 37.76万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-bisphosphonates-bone-controlled-trial/454957
• 关键词: Effect; bisphosphonates; bone; architecture; glucose

Androgen deprivation therapy (ADT) is a type of hormonal treatment which is effective for prostate cancer treatment. However, ADT may cause bone fragility, weight gain, diabetes and heart disease. We will examine the effects of a bone strengthening treatment on bone structure and glucose metabolism in men receiving ADT. This trial should help in better define the risk benefit ratio of ADT, and therefore provide treating doctors with better guidance as to when and how to use this therapy.

雄激素剥夺疗法（ADT）是一种对前列腺癌治疗有效的激素治疗。然而，ADT可能会导致骨脆性、体重增加、糖尿病和心脏病。我们将研究骨强化治疗对接受ADT的男性骨结构和葡萄糖代谢的影响。这项试验应该有助于更好地定义ADT的风险受益比，因此为治疗医生提供更好的指导，以了解何时以及如何使用这种疗法。