COGNITIVE DYSFUNCTION IN KLINEFELTERS SYNDROME & OTHER SEX CHROMOSOME DISORDERS

克兰费尔特综合征的认知功能障碍

• 批准号: 6306684
• 负责人: RONALD Sherwin SWERDLOFF
• 金额: $ 0.1万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6306684
• 关键词: Klinefelter's syndrome; Turner's syndrome; chromosome disorders; clinical research; cognition disorders; dyslexia; human subject; hypogonadism; sex chromosomes

To study the inherited congenital disorders associated with the X and Y chromosomes in patients with Klinefelter's Syndrome, Isochromosome X, and other X and Y conditions and to investigate to what degree these patients suffer from dyslexia and behavioral and learning disabilities. To identify the similarities/differences in the dyslexic phenotype of individuals with XXY, XYY, XXX and isochromosome X Turner's Syndrome subjects. They will be compared to primary hypogonadal XY men,normal gender and age group controls, and subjects with the same karyotype but with minimal or absent dyslexic features.

研究克氏综合征、等染色体X和其他X和Y疾病患者中与X和Y染色体相关的遗传性先天性疾病，并调查这些患者患有阅读障碍、行为和学习障碍的程度。确定XXY、XYY、XXX和等染色体X Turner综合征受试者的睡眠障碍表型的相似性/差异。将他们与原发性性腺功能减退XY男性、正常性别和年龄组对照以及具有相同核型但具有最小或不存在睡眠障碍特征的受试者进行比较。