Antibacterial theranostics based on luminescent metal complexes.

基于发光金属配合物的抗菌治疗诊断学。

• 批准号: 1802687
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1802687
• 关键词: Antibacterial; theranostics; based; luminescent; metal

Multidrug resistance is a huge emerging global challenge. Diseases that were easily treated with antibiotics are increasingly becoming resistant to these drugs And the number of infective bacterial strains that display multiple antibiotic resistances is rapidly increasing. Worryingly, the "development pipeline" for new antibiotics is running dry. This multidisciplinary project involves the synthesis and development of luminescent coordination compounds that not only bind to and image cellular structures through optical microscopy, but display potent bacteriostatic/bactericidal properties against the known pathogen Staphylococcus aureus.The project will include cell biology investigations into the mechanism through which these compounds exert these effects and the chemical synthesis of new compounds designed to optimize their potency. The overall aim of these studies will be the identification and development of a new paradigm for antibiotics

多药抵抗是一个巨大的全球挑战。容易用抗生素治疗的疾病越来越多地对这些药物具有抗药性，并且表现出多种抗生素耐药性的感染细菌菌株的数量正在迅速增加。令人担忧的是，新抗生素的“开发管道”正在干燥。这个多学科的项目涉及发光配位的合成和开发，不仅通过光学显微镜结合和图像细胞结构，而且在已知的病原体葡萄球菌aureus中表现出有效的细菌/杀菌特性。该项目将在这些化合物中构成了这些化学效应的效果，包括这些葡萄球菌的生物学研究，包括启用这些化学效应的效应。这些研究的总体目的是识别和开发抗生素的新范式

项目成果

Using Nanoscopy To Probe the Biological Activity of Antimicrobial Leads That Display Potent Activity against Pathogenic, Multidrug Resistant, Gram-Negative Bacteria.

• DOI: 10.1021/acsnano.8b08440
• 发表时间: 2019-04
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Kirsty L Smitten;Hannah M. Southam;Jorge Bernardino de la Serna;Martin R. Gill;Paul J Jarman;C. Smythe;R. Poole;Jim A. Thomas

Triazole-based osmium(ii) complexes displaying red/near-IR luminescence: antimicrobial activity and super-resolution imaging.

• DOI: 10.1039/d0sc03563g
• 发表时间: 2020-08-07
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Smitten KL;Scattergood PA;Kiker C;Thomas JA;Elliott PIP
• 通讯作者: Elliott PIP

Mononuclear ruthenium(ii) theranostic complexes that function as broad-spectrum antimicrobials in therapeutically resistant pathogens through interaction with DNA.

• DOI: 10.1039/d0sc03410j
• 发表时间: 2020-07-30
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Smitten KL;Thick EJ;Southam HM;Bernardino de la Serna J;Foster SJ;Thomas JA
• 通讯作者: Thomas JA

A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids

• DOI: 10.1021/jacs.9b11313
• 发表时间: 2020-03-11
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Raza, Ahtasham;Archer, Stuart A.;Haycock, John W.
• 通讯作者: Haycock, John W.

Transcriptomic Analysis of the Activity and Mechanism of Action of a Ruthenium(II)-Based Antimicrobial That Induces Minimal Evolution of Pathogen Resistance

诱导病原体抗性最小化进化的钌 (II) 基抗菌药物的活性和作用机制的转录组分析

• DOI: 10.1021/acsptsci.0c00159
• 发表时间: 2020
• 期刊: ACS Pharmacology & Translational Science
• 作者: Varney A