Administrative Core

行政核心

• 批准号: 10712291
• 负责人: DAPHNE A. HAAS-KOGAN
• 金额: $ 5.17万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712291
• 关键词: Accounting; Achievement; Address; Adult; Advisory Committees; Advocate; Archives; Artificial Intelligence; Award; Biometry; Boston; Cancer Biology; Cells; Client; Clinical; Clinical Research; Clinical Trials; Code; Communication; Communication Methods; Communities; Community Services; Computer Models; Dana-Farber Cancer Institute; Daphne plant; Data; Data Science; Data Science Core; Data Set; Databases; Department chair; Doctor of Medicine; Doctor of Philosophy; Education and Outreach; Electronic Mail; Electronics; Evaluation; Face; General Population; Genome; Goals; Grant; Hospitals; Image; Institution; Leadership; Logistics; Machine Learning; Malignant Childhood Neoplasm; Medical; Mission; Molecular; Nature; Occupational activity of managing finances; Oncology; Patient advocacy; Patients; Pediatric Hospitals; Pediatric Oncology; Performance; Persons; Pharmacology; Physics; Pilot Projects; Protocols documentation; Quality of life; Radiation; Radiation Oncology; Reporting; Request for Applications; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Science; Services; Site; Source; Talents; Technology; Text; Training; Videoconferencing; Vision; Woman; Work; cloud based; design; dosimetry; experience; mathematical model; meetings; multidisciplinary; neoplastic cell; outreach program; participant enrollment; pediatric patients; physical science; programs; radiation resistance; radiation response; radioligand; recruit; repository; resistance mechanism; sharing platform; skills; theranostics; tool; web site

The Harvard/UCSF ROBIN Center will address molecular mechanisms of radiation response and resistance in childhood cancers, using the “quieter” genome of pediatric malignancies to identify radiation resistance mechanisms that are broadly applicable to adult and pediatric patients. The Center consists of a Molecular Characterization Trial, two Research Projects, two supporting Cores [one focused on Data Science and Advanced Dosimetry and the second on Imaging and Artificial Intelligence (AI)] as well as the critical Cross- Training Core (ROBIN-NEST). Collectively, these ROBIN Center components can be conceptualized as either “Scientific” or “Programmatic” in nature. Against this backdrop, this Administrative Core has two broad goals. Firstly, as the ROBIN Center’s “inward looking face”, the Administrative Core will support the Scientific and Programmatic missions. Secondly, the Administrative Core will serve as the “outward face” of the Harvard/UCSF Center and as point of contact with NCI, other ROBIN Centers, diverse learners, the radiation sciences workforce, and the lay public. The Administrative Core has three Specific Aims. Aim 1 (Scientific Support): The Administrative Core will implement electronic communication methods to facilitate transfer of accounting information, access to Research and Technology Management forms, access to clinical research databases, and access to cloud-based data and code sharing platforms. Aim 2 (Programmatic Support): The Core will integrate the Harvard/UCSF sites and unify the Center via videoconferencing, in-person meetings, and online communication. Together with the ROBIN-NEST, the Core will host an Annual Retreat to share and harmonize vision and logistics across the ROBIN Center. Finally, the Core will request applications for, evaluate, award, and administer pilot and trans-Network Projects. Aim 3 (NCI and Community Service): The Administrative Core will create the Harvard/UCSF ROBIN Center’s website as a public-facing source of data and resources. Critically, the Core will also work to strengthen the Harvard/UCSF Center with proactive strategies to enhance diversity of our research groups, the radiation sciences workforce, communities served by our Center, and patients enrolled in our clinical trials. Daphne Haas-Kogan, M.D. and Franziska Michor, Ph.D. will serve as co-leaders of the Administrative Core and also as co-PIs of the Harvard/UCSF ROBIN itself. Each of the co-leads has extensive experience in leading multi-investigator, multi-institutional research initiatives. Dr. Haas-Kogan is the Chair of the Department of Radiation Oncology at Dana-Farber Cancer Institute (DFCI), Brigham and Women’s Hospital, and Boston Children’s Hospital, and Dr. Michor has led two iterations of NCI’s Physical Sciences Oncology Network’s (PSON) U54 initiative and also leads the DFCI Physical Sciences Oncology Center (DFCI PSOC). Drs. Haas- Kogan and Michor will be assisted by Simon Maisel, MS, who will report directly to the co-PIs.

哈佛/加州大学旧金山分校罗宾中心将解决辐射反应和抗性的分子机制 在儿童癌症中，使用儿科恶性肿瘤的“安静”基因组来识别辐射抗性 广泛适用于成人和儿童患者的机制。该中心由一个分子 表征试验，两个研究项目，两个支持核心[一个专注于数据科学， 高级剂量学和第二个关于成像和人工智能（AI）]以及关键的交叉- 培训核心（ROBIN-NEST）。总的来说，这些ROBIN中心组件可以概念化为 无论是“科学的”还是“程序的” 在此背景下，该行政核心有两大目标。首先，作为罗宾中心的 “向内看的脸”，行政核心将支持科学和计划任务。第二、 行政核心将作为哈佛/加州大学旧金山分校中心的“外部面孔”和联络点 与NCI，其他罗宾中心，不同的学习者，辐射科学的劳动力，和外行公众。的 行政核心有三个具体目标。 目标1（科学支持）：行政核心将实施电子通信 促进会计信息转移的方法，获得研究和技术管理 表格、访问临床研究数据库以及访问基于云的数据和代码共享平台。 目标2（项目支持）：核心将整合哈佛/加州大学旧金山分校的网站，并统一中心 通过视频会议、面对面会议和在线交流。与ROBIN-NEST一起， 核心将举办年度务虚会，分享和协调整个罗宾中心的愿景和物流。最后， 核心将请求、评估、授予和管理试验和跨网络项目的申请。 目标3（NCI和社区服务）：行政核心将创建哈佛/UCSF 罗宾中心的网站作为一个面向公众的数据和资源来源。重要的是，核心还将努力 加强哈佛/加州大学旧金山分校中心与积极主动的战略，以提高我们的研究小组的多样性， 辐射科学工作者，我们中心服务的社区，以及参加我们临床试验的患者。 Daphne Haas-Kogan，医学博士Franziska Michor博士将担任行政部门的共同领导人， 核心，也作为共同PI的哈佛/加州大学旧金山分校罗宾本身。每一位共同领导人都在以下方面拥有丰富的经验： 领导多研究者、多机构的研究计划。Haas-Kogan博士是该部门的主席 丹娜-法伯癌症研究所（DFCI）、布里格姆妇女医院和波士顿的放射肿瘤学 Michor博士领导了NCI物理科学肿瘤学网络的两次迭代， （PSON）U 54倡议，并领导DFCI物理科学肿瘤中心（DFCI PSOC）。哈斯医生- Kogan和Michor将由Simon Maisel，MS协助，他将直接向共同PI报告。