SSA - Functional analysis of a novel, essential vaccine component of Staphylococcus aureus

SSA - 金黄色葡萄球菌新型重要疫苗成分的功能分析

• 批准号: 1802709
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1802709
• 关键词: SSA; Functional; analysis; novel; essential

Absynth is developing a novel vaccine against the antimicrobial resistant pathogen Staphylococcus aureus based on essential protein antigens. The Foster lab has shown that one of these is required for cell division. The project will aim to analyse the molecular role of cell division components and to assess important domains as vaccinogens. The project will combine protein chemistry, super resolution microscopy and in vivo studies inorder to determine molecular activity and to therefore design specific assay/s for vaccine batch release validation.

Absynth正在开发一种基于基本蛋白抗原的新型疫苗，以对抗抗菌素耐药性病原体金黄色葡萄球菌。福斯特实验室已经表明，其中一个是细胞分裂所必需的。该项目的目的是分析细胞分裂成分的分子作用，并评估作为疫苗原的重要领域。该项目将结合蛋白质化学、超分辨率显微镜和体内研究，以确定分子活性，从而为疫苗批量释放验证设计专门的分析方法/S。