Endocrine-immune reproductive system interactions

这个项目的目的是增加我们对实验动物和人类内分泌和免疫系统之间相互作用的理解。一些免疫系统产物，如细胞因子肿瘤坏死因子- α (tnf - α)、白细胞介素-1和白细胞介素-6 （IL-6）激活下丘脑-垂体-肾上腺轴，并通过它抑制和抑制炎症/免疫反应。微灌注法原位检测人体脂肪

The purpose of this project is to increase our understanding of the interactions between the endocrine and immune systems in both experimental animals and humans. Several immune system products, such as the cytokines Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-1, and Interleukin-6 (IL-6) activate the hypothalamic-pituitary-adrenal axis and through it suppress and restrain the inflammatory/immune response. Human fat examined in situ by microperfusion produces not only leptin, but also TNF-alpha and IL-6. We recently demonstrated that corticotropin-releasing hormone (CRH) is produced locally at sites of inflammation and has profound pro-inflammatory effects at an autocrine/paracrine level. CRH is a potent degranulator of mast cells, a phenomenon that can be inhibited by a nonpeptide CRH antagonist, specific for type 1 receptors called antalarmin. CRH was found in the ovary and endometrium where it may participate in the inflammatory phenomena of ovulation, luteolysis, blastocyst implantation, and menstruation.