Examination of the Hemodynamics of the Portal Venous System in Normal Volunteers

该研究有三个组成部分：技术发展以定义成像方案；对研究对象的血流模式进行观察性研究；定义构造流动模型的解剖结构和流动参数。主要成像方案的制定已经完成；门静脉解剖和血流模式可重复成像。在技术发展期间，我们观察到血流现象的证据，这是我们研究的中心假设。这项观察性研究开始于1999年7月，对象是禁食后和饭后。到目前为止，我们已经累积了22名志愿者。初步的解剖和流动数据已收集用于模型构建；初步建立了模型。参与关键研究的患者已完成磁共振检查；数据分析正在进行中。

There are three components of the study: technical development to define the imaging protocol; conduct the observational study of blood flow patterns in study subjects; define the anatomy and flow parameters for construction of flow models. The development of the principal imaging protocol is complete; the portal anatomy and flow patterns can be reproducibly imaged. During the period of technical development, we have observed evidence of the phenomenon of blood streaming which is the central hypothesis of our study. The observational study of subjects after fasting and after a meal started July 1999. We have accrued 22 volunteers to date. Preliminary anatomic and flow data has been collected for model construction; a preliminary model has been constructed. The magnetic resonance examinations of the patients enrolled in the pivotal study are completed; data analysis is underway.