Examination of the Hemodynamics of the Portal Venous System in Normal Volunteers

正常志愿者门静脉系统血流动力学检查

• 批准号: 6431770
• 负责人: Elizabeth C. Jones
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6431770
• 关键词: HIV infections; Pneumocystis; Pneumocystis pneumonia; bioimaging /biomedical imaging; clinical chemistry; clinical research; communicable disease diagnosis; diagnosis design /evaluation; diagnosis quality /standard; diagnostic respiratory lavage; eating; fasting; hemodynamics; human subject; magnetic resonance imaging; mathematical model; model design /development; opportunistic infections; pentamidine; portal vein; radiography; respiratory disorder diagnosis; sputum; volunteer

There are three components of the study: technical development to define the imaging protocol; conduct the observational study of blood flow patterns in study subjects; define the anatomy and flow parameters for construction of flow models. The development of the principal imaging protocol is complete; the portal anatomy and flow patterns can be reproducibly imaged. During the period of technical development, we have observed evidence of the phenomenon of blood streaming which is the central hypothesis of our study. The observational study of subjects after fasting and after a meal started July 1999. We have accrued 22 volunteers to date. Preliminary anatomic and flow data has been collected for model construction; a preliminary model has been constructed. The magnetic resonance examinations of the patients enrolled in the pivotal study are completed; data analysis is underway.

这项研究包括三个部分：定义成像方案的技术开发；对研究对象的血流模式进行观察研究；定义用于构建血流模型的解剖学和血流参数。主要成像方案的开发已经完成；门静脉解剖和血流模式可以重复成像。在技术发展期间，我们观察到了血液流动现象的证据，这是我们研究的中心假说。对受试者禁食和餐后的观察性研究始于1999年7月。到目前为止，我们已经聚集了22名志愿者。为建立模型收集了初步的解剖和流动数据；初步的模型已经建立。纳入关键研究的患者的磁共振检查已经完成；数据分析正在进行中。