Examination Of The Hemodynamics Of The Portal Venous Sys

门静脉系统血流动力学检查

• 批准号: 6543063
• 负责人: Elizabeth C. Jones
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6543063
• 关键词: HIV infections; Pneumocystis carinii; Pneumocystis pneumonia; anatomy; bioimaging /biomedical imaging; cardiovascular imaging /visualization; clinical research; communicable disease diagnosis; diagnosis design /evaluation; diagnosis quality /standard; diagnostic respiratory lavage; eating; fasting; hemodynamics; human immunodeficiency virus; human subject; magnetic resonance imaging; mathematical model; model design /development; opportunistic infections; pentamidine; physical model; portal vein; radiography; respiratory disorder diagnosis; sputum; volunteer

There are three components of the study: technical development to define the imaging protocol; conduct the observational study of blood flow patterns in study subjects; define the anatomy and flow parameters for construction of flow models. The development of the principal imaging protocol is complete; the portal anatomy and flow patterns can be reproducibly imaged. During the period of technical development, we have observed evidence of the phenomenon of blood streaming which is the central hypothesis of our study. The observational study of subjects after fasting and after a meal started July 1999. We have accrued 22 volunteers to date. Preliminary anatomic and flow data has been collected for model construction; a preliminary model has been constructed. The magnetic resonance examinations of the patients enrolled in the pivotal study are completed. Suitable software for data analysis has become available and data analysis is underway.

研究有三个组成部分：定义成像方案的技术开发;对研究受试者的血流模式进行观察性研究;定义用于构建血流模型的解剖结构和血流参数。主要成像方案的开发已经完成;门静脉解剖结构和血流模式可以重复成像。在技术发展期间，我们已经观察到血液流动现象的证据，这是我们研究的中心假设。空腹和餐后受试者的观察性研究于1999年7月开始。到目前为止，我们已经招募了22名志愿者。初步的解剖和流动数据已收集的模型构建;一个初步的模型已经建成。完成了入组关键研究的患者的磁共振检查。已经有了适当的数据分析软件，数据分析正在进行中。