Hemodynamics of the Portal Venous System in Normal Volunteers using MRI

使用 MRI 观察正常志愿者门静脉系统的血流动力学

• 批准号: 6227865
• 负责人: Elizabeth C. Jones
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6227865
• 关键词: bioimaging /biomedical imaging; clinical research; eating; fasting; hemodynamics; human subject; magnetic resonance imaging; mathematical model; model design /development; portal vein; volunteer

There are three components of the study: technical development to define the imaging protocol; conduct the observational study of blood flow patterns in study subjects; and define the anatomy and flow parameters for construction of flow models. The development of the principal imaging protocol is complete; the portal anatomy and flow patterns can be reproducibly imaged. During the period of technical development, we have observed evidence of the phenomenon of blood streaming, which is the central hypothesis of our study. The observational study of subjects after fasting and after a meal began in July 1999. Preliminary anatomic and flow data have been collected for model construction; a preliminary model has been constructed. We expect to refine the model and initiate the flow studies within the next few months and continue the study.

研究有三个组成部分：定义成像方案的技术开发;对研究受试者的血流模式进行观察性研究;以及定义用于构建血流模型的解剖结构和血流参数。主要成像方案的开发已经完成;门静脉解剖结构和血流模式可以重复成像。在技术发展期间，我们观察到了血液流动现象的证据，这是我们研究的中心假设。空腹和餐后受试者的观察性研究于1999年7月开始。初步的解剖和流动数据已收集的模型构建;一个初步的模型已经建成。我们预期在未来数月内会改善模型，展开水流研究，并继续进行研究。