ADAPTING BEHAVIORAL MARITAL THERAPY TO TREAT DRUG ABUSE

R 01 DA 10835 -01的第二次修订，最初提交日期为2/96 （评分为225），然后2/97（评分为179），为3年I期 研究计划是为了响应NIDA行为疗法 发展计划。 它开发了一个婚姻治疗模型， 为滥用药物或依赖药物的男性及其女性提供的治疗 通过修改目前用于治疗的类似模型， 酒精依赖 评估/治疗手册将 通过治疗三组每组8对夫妇而开发的。 变化 根据每个队列的经验， 纳入后续队列的治疗手册中。 这项研究的主要目标是开始有计划地 开发一种有前途的药物行为伴侣治疗方法 成瘾（BCTD），并生成治疗手册，相关 第二阶段研究的材料和描述性数据。 具体 主要目标是：（1）制定一个可行的， 治疗方案的独立，门诊认知- 行为伴侣治疗药物成瘾;（2）开发 基线（BL）和随访（FU）评估组合 研究精神病理学，物质使用， 和婚姻关系的质量，对BCTD的反应， (3)生成自我报告、访谈和观察数据， 每对夫妇，这样我们就可以仔细描述样本， BL术语和治疗后特征，以及婚姻 互动与我们的变革模式密切相关。 这些 描述性数据将有助于开发治疗方法 适用于广泛药物滥用的议定书 个人，以及与变化有关的假设， 在第二阶段的后期研究中进行测试。 具体的次要目标是： (4)为治疗师制定甄选和培训方案; (5)制定治疗师依从性/能力的衡量标准;（6） 制定治疗完整性的衡量标准，以及（7）评估 跟踪这一样本的可行性。 研究设计和 方法：首先，我们将编写一份BCTD治疗手册， 滥用、BL和FU评估组合， 以及一系列的治疗和治疗过程 措施 评估/治疗包将包括BL 评估24次门诊联合治疗，治疗后随访和 离职面谈，以及3个月随访和离职面谈。 初始 该协议的版本将在前六年开发 几个月，通过修改现有的协议，酒精行为 夫妻治疗 第一年下半年，8 将招募夫妇，并试行初步方案， 修订。 另外八对夫妇将组成第二批， 修订后的评估/治疗方案 补助金的第二年。 该手册将再次修订， 最后一批8对夫妇将试行“最接近最终”的版本， 评估/治疗/随访计划的最后一年， 补助金 最后的修订将根据第三次会议的结果进行。 小组试点，手册和议定书将编写用于 治疗的后续测试。

This second revision of R01DA10835-01, originally submitted 2/96 (score was 225) then 2/97 (score was 179), is a 3 year, Stage I research plan is in response to the NIDA Behavioral Therapies Development Program. It develops a marital therapy model of treatment for drug abusing or dependent males and their female partners, by modifying a similar model currently used to treat alcohol dependence. The assessment/treatment manual will be developed by treating three cohorts of 8 couples each. Changes in the protocol based on experiences with each cohort will be incorporated into the treatment manual for the subsequent cohort. Broad objectives of the study are to begin programmatic development of a promising behavioral couples treatment for drug addiction (BCTD), and to generate a treatment manual, related materials, and descriptive data for Stage II research. Specific primary goals are: (1) to develop a feasible, manualized treatment protocol for stand-alone, outpatient cognitive- behavioral couples therapy for drug addiction; (2) to develop baseline (BL) and follow-up (FU) assessment batteries for both partners, to study the effects of psychopathology, substance use, and quality of the marital relationship, on response to BCTD, and (3) to generate self-report, interview, and observational data on each couple, so that we can carefully describe the sample in terms of BL and post-treatment characteristics, and marital interaction specifically related our model of change. These descriptive data will facilitate development of a treatment protocol that is applicable to wide range of drug abusing individuals, and of hypotheses related to change, that can be tested in later Stage II studies. Specific secondary goals are: (4) to develop selection and training protocols for therapists; (5) to develop a measure of therapist adherence/competence; (6) to develop a measure of treatment integrity, and (7) to evaluate the feasibility of following up this sample. Research Design and Methods: First, we will prepare a BCTD treatment manual for drug misuse, BL and FU assessment batteries, a training protocol for therapists, and a battery of treatment and therapist process measures. The assessment/treatment package will include BL assessment 24 outpatient conjoint sessions, post-treatment FU and exit interview, and a 3 month FU and exit interview. The initial version of the protocols will be developed in the first six months, by modifying existing protocols for alcohol behavioral couples therapy. During the second half of the first year, 8 couples will be recruited and the initial protocol will be piloted and revised. Eight more couples will comprise the second cohort and will be administered the revised assessment/treatment protocol during the second year of the grant. The manual will then be revised again, and the final cohort of 8 couples will pilot the "closest to final" version of the assessment/treatment/ follow-up package during the last year of the grant. Final revisions will be made based on results from the third cohort pilot, and the manual and protocols will be prepared for used in subsequent tests of the treatment.