ALCOHOL SUBTYPES--STUDY OF CLINICAL VALIDITY

就几个维度而言，酗酒者是一个不同的群体 包括家族史、共病精神病和饮酒史。 一个有用和可靠的酗酒者分类系统将 促进患者与治疗匹配和病因学研究 酗酒。已经提出了许多子类型模式，但没有一个 已经被接受为最终决定。事实上，有几个流行的 多维类型学还没有被充分复制。仅限 据报道，两项研究测试了相互竞争的类型学 判别效度和预测效度。没有任何尝试整合 提出的类型学转化为非冗余子类型的有理集合 模式。此外，在使用的方式上也不一致 将特定子类型和诊断方法用于 对科目进行分类。本研究的主要目的是：(1)测试 两种多维经验派生类型的可复制性 (键入A/B/和I/II)。两个多维的，理论上推导出来的 类型学(二维和多综合征模型)，以及四个 一维的、理论派生的类型学(反社会人格 障碍(ASP)与非ASP、早发与晚发、家族史(FH) 阳性与FH阴性，以及性别)在许多治疗环境中 和研究不足的样本；以及(2)测试预测效度 在不同的治疗环境中的流行类型。类型学将 就它们所占的差异进行相互比较 在治疗结果方面，与其他预后指标相比，如 年龄、教育程度和治疗因素。治疗结果通过以下方式衡量 多个领域，包括饮酒、心理社会功能和 治疗依从性。本研究的次要目标包括：(3) 检查类型之间的收敛(重叠)，以及(4)测试 重复亚型的判别效度。这项研究将使用基线 (BL)和随访(FU)数据收集自四个不同的治疗- 罗格斯大学酒精研究中心(ARC)的结果研究 加上来自补充样本的数据，其中BL值和FU值将是 作为当前赠款的一部分筹集的。775名受试者的总样本 因此包括675个ARC和100个补充对象(548名男性和227名 女性)谁将接受共同的BL和FU“核心评估单元” 有关饮酒史、共病精神病、个性和 性情、酒精和药物使用障碍家族史、反社会 个性和抑郁，以及心理社会功能。

Alcoholics are a heterogeneous group in terms of several dimensions including family history, comorbid psychopathology, and drinking history. A useful and reliable classification system for alcoholics would facilitate patient-treatment matching and research on etiology of alcoholism. A number of subtyping schemas have been proposed, and none have been accepted as definitive. In fact,several prevailing multidimensional typologies have not yet been replicated adequately. Only two reported studies have tested competing typologies in terms of discriminant and predictive validity. There has no attempt to integrate proposed typologies into a rational set of non-redundant subtyping schemas. Furthermore, there has been inconsistency in ways used to operationalize specific subtypes and in the diagnostic methodology used to classify subjects. The primary aims of the current study are: (1) to test replicability of two multidimensional, empirically derived typologies (Type A/B/, and I/II). two multidimensional, theoretically derived typologies (bidimensional and polysyndromatic models), and four unidimensional, theoretically derived typologies (antisocial personality disorder (ASP) versus nonASP, early versus late onset, family history (FH) positive versus FH negative, and gender) in a number of treatment settings and understudied samples; and (2) to test predictive validity of prevailing typologies within diverse treatment settings. Typologies will be compared vis a vis one another regarding the variance they account for in treatment outcome, and vis a vis other prognostic indicators such as age, education, and treatment factors. Treatment outcome is measured via multiple domains including drinking, psychosocial functioning, and treatment compliance. Secondary aims of the current study include: (3) to examine convergence (overlap) among typologies, and (4) to test discriminant validity of replicated subtypes. The study will use baseline (BL) and follow-up (FU) data collected from four separate treatment- outcome studies at the Rutgers University Alcohol Research Center (ARC), plus data from a supplementary sample for whom BL and FU data will be collected as part of the current grant. The total sample of 775 subjects thus includes 675 ARC and 100 supplemental subjects (548 men and 227 women) who will undergo a common "core assessment battery" for BL and FU information on drinking history, comorbid psychopathology, personality and temperament, family history of alcohol and drug use disorders, antisocial personality and depression, and psychosocial functioning.