ACUPUNCTURE AND COPING SKILLS TRAINING FOR COCAINE ABUSE

描述：(申请人摘要) 这一相互竞争的续订要求资金继续我们的研究调查 耳针治疗可卡因成瘾。在上一次 在授权期内，我们进行了三项临床研究，共纳入211名患者。每个人 研究比较耳针和两种对照条件--针 使用耳廓螺旋部位的插入控制，以及放松组- 在各种情况下，有没有广泛使用的心理社会 治疗(应对技能培训--CST)以及财政奖励 出席率。研究结果支持针灸的疗效 与科技委合作，在没有财政奖励的情况下。然而，这些研究 不是被设计来明确地研究针灸之间的相互作用 和CST，或确定针灸是否比CST更有效 一个人送来的。拟议的研究建立在我们之前的研究基础上，并将 研究两种广泛使用的疗法及其相互作用--针灸和 CST--在临床环境中，每种治疗都是由物质提供的 虐待辅导员，采用与需要一致的研究设计 临床实践的研究成果，以及其中每个研究成果的相对成本 治疗也在考虑之列。我们建议进行“第三期”临床试验。 在200名可卡因滥用美沙酮维持患者的试验中，所有患者都接受了 标准美沙酮维持治疗，将随机分配到4人 治疗条件，每次12周，每次2次(针灸/NO 针灸)2次(每周应对技能训练组/无应对技能 培训)析因设计。四组分别为：(1)单纯针刺组； (B)仅提供应对技能培训(CST)；。(C)针灸加应对技能。 培训(ACU+CST)；(D)仅标准美沙酮维持(MM)。一秒钟内 研究阶段，以探索这些治疗的有效性 在预防复发方面，在为期12周的试验中开始禁欲的患者 将被邀请继续他们分配的治疗6个月。两者都有 临床疗效、成本以及治疗/患者匹配变量将 接受检查。

DESCRIPTION: (Applicant's Abstract) This competing renewal requests funds to continue our research investigating auricular acupuncture as a treatment for cocaine addiction. In the previous grant period we conducted three clinical studies enrolling 211 patients. Each study compared auricular acupuncture to two control conditions - a needle insertion control using sites in the auricle helix, and a relaxation group - under a variety of conditions, with and without a widely used psychosocial treatment (Coping Skills Training - CST) as well as financial incentives for attendance. Findings supported the efficacy of acupuncture when provided in conjunction with CST and without financial incentives. However, these studies were not designed to definitively examine the interaction between acupuncture and CST, or to determine whether acupuncture is more effective than CST delivered alone. The proposed study builds upon our previous research and will investigate two widely used treatments and their interactions - acupuncture and CST - in a clinical context in which each treatment is provided by substance abuse counselors, employing a research design consistent with the need to bring research findings to clinical practice, and in which relative cost of each treatment is also considered. We propose to conduct a "Phase III" clinical trial in which 200 cocaine-abusing methadone maintained patients, all receiving standard methadone maintenance treatment, will be randomly assigned to 4 treatment conditions, each of 12 weeks duration, in a 2 (acupuncture/no acupuncture) by 2 (weekly coping skills training group/no coping skills training) factorial design. The four groups are: (a) acupuncture only (ACU); (b) coping skills training only (CST); (c) acupuncture plus coping skills training (ACU+CST); (d) standard methadone maintenance only (MM). In a second phase of the study, in order to explore the effectiveness of these treatments in preventing relapse, patients who initiate abstinence in the 12-week trial will be invited to continue their assigned treatment for 6 months. Both clinical efficacy, cost, as well as treatment/patient matching variables, will be examined.