Root rot resistance: using a model to help a crop

抗根腐病：使用模型来帮助作物

• 批准号: 1805734
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1805734
• 关键词: Root; rot; resistance; using; model

Wheat is the most important European crop. Fusarium Head Blight (FHB) is a major threat to wheat production. FHB reduces yield and leads to the accumulation of mycotoxins such as deoxynivalenol (DON) in grain. Wheat is a relatively large plant with a long life cycle and highly complex genome making it difficult to study interactions with Fusarium. In contrast Brachypodium distachyon (Bd) has a fully sequenced genome, small stature and short lifecycle making it ideal as a model to study interactions between Fusarium and grass species. The current project represents collaboration between the John Innes Centre and BASF, one of the worlds leading chemical companies. The project will develop the model further to identify Bd accessions with ideal characteristics to serve as full models for evaluation fungicide efficacy. The project will include detailed histological comparison of infection of Bd and wheat by Fusarium. This will be complemented by comparative gene-expression studies to explore the full extent of similarities in response of the two hosts to Fusarium and its toxic metabolites. This studies will provide new insights into fungal virulence and host resistance. The student will extend the Bracypodium system to fungicide efficacy trials under the guidance of BASF scientists to develop a high throughput screening system. The project provides an outstanding opportunity to undertake fundamental study of plant-pathogen interactions and translate these to develop practical approaches to crop protection.

小麦是欧洲最重要的农作物。赤霉病 (FHB) 是小麦生产的主要威胁。 FHB 会降低产量并导致谷物中脱氧雪腐镰刀菌烯醇 (DON) 等霉菌毒素的积累。小麦是一种相对较大的植物，具有较长的生命周期和高度复杂的基因组，因此很难研究与镰刀菌的相互作用。相比之下，二穗短柄草 (Bd) 具有完全测序的基因组、较小的身材和较短的生命周期，使其成为研究镰刀菌和禾本科植物之间相互作用的理想模型。当前的项目代表了约翰·英尼斯中心与世界领先的化学公司之一巴斯夫之间的合作。该项目将进一步开发该模型，以确定具有理想特性的 Bd 种质，作为评估杀菌剂功效的完整模型。该项目将包括镰刀菌感染 Bd 和小麦的详细组织学比较。这将通过比较基因表达研究来补充，以探索两种宿主对镰刀菌及其有毒代谢物的反应的全部相似性。这项研究将为真菌毒力和宿主抵抗力提供​​新的见解。该学生将在巴斯夫科学家的指导下将Bracypodium系统扩展到杀菌剂功效试验中，开发高通量筛选系统。该项目提供了一个绝佳的机会，可以进行植物与病原体相互作用的基础研究，并将其转化为开发作物保护的实用方法。