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MOUSE MODEL--TARGETED GENE KNOCK-OUT OF PROSTAGLANDIN SYNTHASE I AND II

MOUSE MODEL--TARGETED GENE KNOCK-OUT OF PROSTAGLANDIN SYNTHASE I AND II
小鼠模型——前列腺素合成酶I和II的靶向基因敲除
批准号：
6432237
负责人：
Robert Langenbach
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6432237
关键词：
adenomatous polyps carcinogen testing chemical carcinogen chemical carcinogenesis colorectal neoplasms cutaneous papilloma disease /disorder model gene targeting genetically modified animals laboratory mouse mutagen testing mutagens neoplasm /cancer genetics nonsteroidal antiinflammatory agent phorbols prostaglandin E prostaglandin endoperoxide synthase toxicology

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Summary of Work: A series of projects to elucidate the physiological functions of the individual cyclooxygenase (COX) isoforms are ongoing with the COX knockout mice. Mice deficient in both COX1 and COX2 have been produced. These mice, and mice carrying only a single copy of one of the COX genes, are being used to determine the physiological roles of the individual COX isoforms and to elucidate the ways in which the two isoforms act individually or in conjunction. Mice deficient in both isoforms die shortly after birth of patent ductus arteriosus, but are otherwise developmentally normal.
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