Development of a novel multiplex LDI source for aerosol microdroplet/microreactor production and mass spectrometry (MS) analysis

该项目的基础是我们最近在使用激光解吸/电离（LDI）的质谱仪内监测气相中的（生物）化学反应方面的进展和成功。提出了开发、研究和优化多重LDI的分析能力，用于产生将在质谱仪的离子源中融合的大量微滴/反应器羽流，启动快速（生物）化学反应并通过质谱（MS）对其进行分析，通过每隔几百微秒同时测定所有物质的分子量，到目前为止，通过MS的快速气相反应监测仅在最近通过喷雾电离方法如电喷雾电离（ESI）和解吸电喷雾电离（DESI）证明。

TThe basis for this project is our recent progress and success in monitoring (bio)chemical reactions in the gas phase within a mass spectrometer using laser desorption/ionization (LDI). It is proposed to develop, investigate and optimise the analytical power of multiplex LDI for producing a multitude of plumes of microdroplets/reactors that will fuse in the ion source of a mass spectrometer, initiating fast (bio)chemical reactions and their analysis by mass spectrometry (MS), which through the simultaneous determination of the molecular mass of all species every few hundred microseconds allows the rapid and extremely well time-resolved characterisation of the (bio)chemical reactions.Thus far, fast gas-phase reaction monitoring by MS has only been demonstrated very recently by spray ionization methods such as electrospray ionization (ESI) and desorption electrospray ionization (DESI).