fMRI of Striatal Systems for Memory: Parkinson's Disease

描述（由申请人提供）：拟议项目旨在使用 功能性磁共振成像（fMRI）检查的关系 帕金森氏病（PD）的记忆缺陷与 额纹状体功能加深我们对 额纹状体系统在PD中的功能性破坏对于增加PD的发病率至关重要。 我们对帕金森病相关认知和神经缺陷的了解， 以及产生有针对性的神经药理学和行为策略 来减轻这种疾病的衰弱影响。额纹的 已知通路在PD中受到影响。这些途径是关键的组成部分 支持工作记忆的神经回路， 长期记忆，所有这些都在PD中受损。在这项提案中， 提供了直接测量生理功能障碍， 额纹状体通路在不同的记忆任务的性能。中 一系列的4个实验，功能磁共振成像是用来评估功能的完整性， PD患者和对照受试者在1.显式 内隐序列学习; 2.空间和非空间工作记忆; 3。 执行长期检索任务，以及4。表演口头和 图片编码任务。这种短期和长期的电池，和隐含的， 外显记忆任务用于定义功能动力学的差异 额纹状体回路的变化我们的中心假设是 在PD中发现的缺陷反映了额纹状体回路内的处理改变。 第二个假设是，额外的记忆系统，包括内侧记忆系统， 颞叶-前额叶网络相对不受疾病的影响。的fMRI 预期数据与PD患者的记忆性能结果相结合 提供有关PD的信息，直接联系特定的功能障碍， 额纹状体通路与工作记忆的特定损伤， 外显和内隐长期记忆任务。拟议的研究是 重要的是，这些发现将有助于我们了解 不同类型记忆障碍的功能神经解剖学基础 警局通过进一步描述和定义记忆的大脑区域 这些研究将增加我们对PD如何干扰 期间的认知功能

DESCRIPTION (provided by applicant): The proposed project aims to use functional magnetic resonance imaging (fMRI) to examine the relationship between memory deficits in Parkinson's disease (PD) and underlying changes in frontostriatal functioning. Increasing our understanding of how the frontostriatal system is functionally disrupted in PD is crucial for increasing our knowledge about the cognitive and neurological deficits associated with PD, and also for generating targeted neuropharmacological and behavioral strategies for alleviating the debilitating effects of the disease. Frontostriatal pathways are known to be affected in PD. These pathways are critical components of neural circuits supporting working memory and explicit and implicit long-term memory, all of which are impaired in PD. In this proposal, fMRI provides direct measurements of physiological dysfunction within particular frontostriatal pathways during performance of different memory tasks. In a series of 4 experiments, fMRI is used to assess the functional integrity of frontostriatal circuitry in PD patients and control subjects during 1. Explicit and implicit sequence learning; 2. Spatial and non-spatial working memory; 3. Performance of a long-term retrieval task, and 4. Performance of verbal and picture encoding tasks. This battery of short and long-term, and implicit and explicit memory tasks is used to define differences in the functional dynamics of frontostriatal circuits in PD. Our central hypothesis is that the memory deficits found in PD reflect altered processing within frontostriatal circuits. A secondary hypothesis is that additional memory systems, including the medial temporal-prefrontal network, are relatively spared by the disease. The fMRI data combined with the memory performance findings with PD patients is expected to provide information about PD that directly links dysfunction of particular frontostriatal pathways with specific impairments on working memory and explicit and implicit long-term memory tasks. The proposed studies are significant, as the findings will contribute to our understanding of the functional neuroanatomy underlying different types of memory disturbances in PD. By further characterizing and defining brain areas underlying memory disturbances in PD, the studies will add to our knowledge of how PD disrupts cognitive function during.