fMRI of Striatal Systems for Memory: Parkinson's Disease

记忆纹状体系统的功能磁共振成像：帕金森病

• 批准号: 6480184
• 负责人: CHANTAL E. STERN
• 金额: $ 16.92万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6480184
• 关键词: Parkinson's disease; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; clinical research; corpus striatum; functional magnetic resonance imaging; human subject; memory disorders; method development; neural information processing; neural transmission; neuropathology; neuropsychological tests; neuropsychology

DESCRIPTION (provided by applicant): The proposed project aims to use functional magnetic resonance imaging (fMRI) to examine the relationship between memory deficits in Parkinson's disease (PD) and underlying changes in frontostriatal functioning. Increasing our understanding of how the frontostriatal system is functionally disrupted in PD is crucial for increasing our knowledge about the cognitive and neurological deficits associated with PD, and also for generating targeted neuropharmacological and behavioral strategies for alleviating the debilitating effects of the disease. Frontostriatal pathways are known to be affected in PD. These pathways are critical components of neural circuits supporting working memory and explicit and implicit long-term memory, all of which are impaired in PD. In this proposal, fMRI provides direct measurements of physiological dysfunction within particular frontostriatal pathways during performance of different memory tasks. In a series of 4 experiments, fMRI is used to assess the functional integrity of frontostriatal circuitry in PD patients and control subjects during 1. Explicit and implicit sequence learning; 2. Spatial and non-spatial working memory; 3. Performance of a long-term retrieval task, and 4. Performance of verbal and picture encoding tasks. This battery of short and long-term, and implicit and explicit memory tasks is used to define differences in the functional dynamics of frontostriatal circuits in PD. Our central hypothesis is that the memory deficits found in PD reflect altered processing within frontostriatal circuits. A secondary hypothesis is that additional memory systems, including the medial temporal-prefrontal network, are relatively spared by the disease. The fMRI data combined with the memory performance findings with PD patients is expected to provide information about PD that directly links dysfunction of particular frontostriatal pathways with specific impairments on working memory and explicit and implicit long-term memory tasks. The proposed studies are significant, as the findings will contribute to our understanding of the functional neuroanatomy underlying different types of memory disturbances in PD. By further characterizing and defining brain areas underlying memory disturbances in PD, the studies will add to our knowledge of how PD disrupts cognitive function during.

描述(申请人提供)：拟申请项目旨在使用 功能磁共振成像(FMRI)检查两者之间的关系 帕金森氏病(PD)的记忆缺陷和潜在的 额纹状体功能。加深了我们对 额纹状体系统功能紊乱是帕金森病患者增加的关键 我们对与帕金森病相关的认知和神经缺陷的了解， 也用于产生有针对性的神经药理学和行为策略 以减轻疾病的衰弱作用。额纹状体 众所周知，帕金森病的通路会受到影响。这些通路是关键的组成部分 支持工作记忆和外显和内隐的神经回路 长期记忆，所有这些都在帕金森氏病中受损。在本提案中，功能磁共振成像 提供生理功能障碍的直接测量，特别是 不同记忆任务执行过程中的额纹状体通路。在一个 一系列的4个实验，使用功能磁共振成像来评估功能完整性 帕金森病患者和对照组的额纹状体环路1.外显 和内隐序列学习；2.空间和非空间工作记忆； 长期提取任务的表现，以及4.言语和语言的表现 图片编码任务。这一系列的短期和长期，以及隐含和 外显记忆任务被用来定义功能动态的差异 帕金森病患者的额纹状体环路。我们的中心假设是记忆 帕金森病中发现的缺陷反映了额纹状体回路内处理的改变。 第二个假设是额外的记忆系统，包括内侧 颞叶-前额叶网络，相对不受疾病的影响。功能磁共振成像 结合帕金森病患者的记忆表现结果的数据是可望的 提供有关帕金森病的信息，这些信息直接与特定的功能障碍有关 额纹状体通路对工作记忆和工作记忆的特殊损害 外显和内隐的长时记忆任务。建议进行的研究包括 由于这些发现将有助于我们理解 不同类型记忆障碍的功能神经解剖学基础 警察。通过进一步描述和定义记忆下的大脑区域 PD中的干扰，这些研究将增加我们对PD如何破坏的知识 认知功能的过程中。