COGNITIVE CHANGE IN HIV: A FMRI STUDY

HIV 的认知变化：FMRI 研究

• 批准号: 6663134
• 负责人: CHANTAL E. STERN
• 金额: $ 29.87万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2005-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6663134
• 关键词: AIDS /HIV neuropathy; AIDS dementia complex; HIV infections; antiAIDS agent; basal ganglia; bioimaging /biomedical imaging; brain electrical activity; brain mapping; clinical research; cognition; corpus striatum; functional magnetic resonance imaging; helper T lymphocyte; human subject; neuropathology; neuropsychological tests; neuropsychology; prefrontal lobe /cortex; psychomotor function; quality of life; short term memory; testosterone; thalamus; virus load

HIV infection is often accompanied by cognitive, motor, and behavioral changes that range from mild impairments of memory, concentration and motor slowing to HIV-associated dementia. These types of changes resemble the neuropsychological profiles of individuals with subcortical neuropathology, including Parkinson's disease (PD) and Huntington's disease (HD). Studies have also shown HIV to have pathology similar to PD and HD, with post-mortem, structural neuroimaging, and resting metabolic imaging studies showing damage primarily to the basal ganglia and thalamus. The only reported cognitive activation study, used PET to show prefrontal cortex dysfunction in HIV-positive subjects during a short-term memory task. All of this evidence suggests dysfunction of the circuits linking the prefrontal cortex, basal ganglia, and thalamus in the brains of HIV-infected individuals. However, there is limited data that directly links HIV-related cognitive impairments with function in any brain areas, including frontostriatal regions. The main goal of this study is to integrate functional MRI (fMRI), neuropsychological measurements, immunological markers, and measures of everyday functioning to study the relationship between HIV-related cognitive, motor, and behavioral deficits and underlying changes in functional brain circuitry. Data will be collected in a group of 150 HIV-positive, non-demented subjects and 50 HIV-negative control subjects. The specific aims of the proposal are: 1) to characterize the relationship between viral load, CD4+ count and brain function, 2) to use fMRI to assess brain function during performance of cognitive tasks found to be impaired in HIV-infected individuals, especially those that are related to frontostriatal function, 3) to examine the relationship between brain function, standard neuropsychological tests that are sensitive to HIV, and everyday functioning and 4) to analyze whether such relationships are moderated by factors including antiretroviral therapy use, age, ethnicity, education, or premorbid intelligence. The opportunity to use current fMRI methodology is a major strength of this study as it permits examination of brain function in a single subject. As HIV is a very heterogeneous disorder, it will be important to evaluate the relationship between the experimental variables within single subjects to better understand how each variable directly impacts the others. Finally, data produced by this study may lead to a more sophisticated understanding of the nature of brain dysfunction in HIV, assisting in the development of therapies to ameliorate cognitive impairment by targeting brain regions affected earliest by the disease.

HIV infection is often accompanied by cognitive, motor, and behavioral changes that range from mild impairments of memory, concentration and motor slowing to HIV-associated dementia. These types of changes resemble the neuropsychological profiles of individuals with subcortical neuropathology, including Parkinson's disease (PD) and Huntington's disease (HD). Studies have also shown HIV to have pathology similar to PD and HD, with post-mortem, structural neuroimaging, and resting metabolic imaging studies showing damage primarily to the basal ganglia and thalamus. The only reported cognitive activation study, used PET to show prefrontal cortex dysfunction in HIV-positive subjects during a short-term memory task. All of this evidence suggests dysfunction of the circuits linking the prefrontal cortex, basal ganglia, and thalamus in the brains of HIV-infected individuals. However, there is limited data that directly links HIV-related cognitive impairments with function in any brain areas, including frontostriatal regions. The main goal of this study is to integrate functional MRI (fMRI), neuropsychological measurements, immunological markers, and measures of everyday functioning to study the relationship between HIV-related cognitive, motor, and behavioral deficits and underlying changes in functional brain circuitry. Data will be collected in a group of 150 HIV-positive, non-demented subjects and 50 HIV-negative control subjects. The specific aims of the proposal are: 1) to characterize the relationship between viral load, CD4+ count and brain function, 2) to use fMRI to assess brain function during performance of cognitive tasks found to be impaired in HIV-infected individuals, especially those that are related to frontostriatal function, 3) to examine the relationship between brain function, standard neuropsychological tests that are sensitive to HIV, and everyday functioning and 4) to analyze whether such relationships are moderated by factors including antiretroviral therapy use, age, ethnicity, education, or premorbid intelligence. The opportunity to use current fMRI methodology is a major strength of this study as it permits examination of brain function in a single subject. As HIV is a very heterogeneous disorder, it will be important to evaluate the relationship between the experimental variables within single subjects to better understand how each variable directly impacts the others. Finally, data produced by this study may lead to a more sophisticated understanding of the nature of brain dysfunction in HIV, assisting in the development of therapies to ameliorate cognitive impairment by targeting brain regions affected earliest by the disease.