OPIATE ACTIONS ON THE VASCULAR MICROENVIRONMENT

阿片类药物对血管微环境的作用

• 批准号: 6564010
• 负责人: GEORGE B STEFANO
• 金额: $ 19.12万
• 依托单位: COLLEGE AT OLD WESTBURY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-15 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564010
• 关键词: HIV envelope protein gp120; cellular immunity; drug abuse; granulocyte; human tissue; immunocytochemistry; immunoregulation; leukocytes; lymphocyte; minority institution research support; neuroimmunomodulation; neuropeptides; opioid receptor; second messengers; vascular endothelium

The proposed Old Westbury Neuroscience Research Institute will increase the research potential of the SUNY/College at Old Westbury, the faculty and our minority undergraduate students. The goal for the immediate future will be to provide research support for the faculty so that they may obtain R01-type grants, create an environment for the further development of research at the College and increase minority student representation in graduate programs. Over the longer term, the goal will be to increase the numbers of minority students in careers in mental health and drug abuse treatment and prevention. The College is ideally suited to carry out this mission because it has a high percentage of minority students who choose science as a major and a faculty experienced in research and the training of students in neuroscience research with special interests in molecular and cellular approaches. The proposed MIRDP student curriculum is built on a core mental health-neuroscience concentration that already exists. The MIRDP faculty and students will be involved with modern neurobiological-immune techniques (receptor binding, neuroendocrine/behavior, neurotransmitter/ modulator identification, image analysis), and will work as well on many levels (molecular, cellular and organismic) concerned with the elucidating neuropeptide mechanisms. The program will provide seminars/lectures and workshops related to ADAMHA areas. The students will have an opportunity to earn entrance into the existing ADAMHA-MARC Program as well as our Society for Neuroscience Chapter. Our program stresses meritorious mental health-drug abuse research as an immediate goal or measure of our activity. The career choices of the students will be broadened, and their expertise and awareness of mental health and related areas will increase. This program offers a strong "wet-lab" foundation to foster mental health and drug abuse interests and build on these areas as career options as well as develop both faculty research and institutional advancement in this area.

拟议中的老韦斯特伯里神经科学研究所将增加 纽约州立大学/旧韦斯特伯里学院的研究潜力，教师和我们的 少数民族大学生。近期的目标是 为教师提供研究支持，以便他们可以获得 R 01型赠款，为进一步发展创造环境， 研究在学院和增加少数民族学生的代表性， 研究生课程。从长远来看，目标将是增加 从事精神卫生和药物滥用职业的少数民族学生人数 治疗和预防。学院非常适合开展这项工作。 使命，因为它有一个高比例的少数民族学生谁选择 科学作为一个主要的和教师在研究和培训经验丰富， 对分子生物学有特殊兴趣的神经科学研究的学生 和细胞方法。拟议的MIRDP学生课程是建立在 一个已经存在的核心精神健康神经科学集中。的 MIRDP教师和学生将参与现代 神经生物免疫技术（受体结合， 神经内分泌/行为，神经递质/调节剂识别，图像 分析），并将在许多层面（分子，细胞和 器官）与阐明神经肽机制有关。的 该计划将提供与ADAMHA相关的研讨会/讲座和讲习班 地区学生将有机会获得进入 现有的ADAMHA-MARC项目以及我们的神经科学学会 章我们的计划强调有价值的心理健康药物滥用研究 作为我们活动的直接目标或衡量标准。的职业选择 学生将得到拓宽，他们的专业知识和心理意识， 卫生及相关领域将有所增加。该计划提供了一个强大的 “湿实验室”基金会，以促进精神健康和药物滥用的利益， 建立在这些领域作为职业选择，以及发展两个教师 在这方面的研究和体制建设。