OPIATE ACTIONS ON THE VASCULAR MICROENVIRONMENT

阿片类药物对血管微环境的作用

• 批准号: 6564010
• 负责人: GEORGE B STEFANO
• 金额: $ 19.12万
• 依托单位: COLLEGE AT OLD WESTBURY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-15 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564010
• 关键词: HIV envelope protein gp120; cellular immunity; drug abuse; granulocyte; human tissue; immunocytochemistry; immunoregulation; leukocytes; lymphocyte; minority institution research support; neuroimmunomodulation; neuropeptides; opioid receptor; second messengers; vascular endothelium

The proposed Old Westbury Neuroscience Research Institute will increase the research potential of the SUNY/College at Old Westbury, the faculty and our minority undergraduate students. The goal for the immediate future will be to provide research support for the faculty so that they may obtain R01-type grants, create an environment for the further development of research at the College and increase minority student representation in graduate programs. Over the longer term, the goal will be to increase the numbers of minority students in careers in mental health and drug abuse treatment and prevention. The College is ideally suited to carry out this mission because it has a high percentage of minority students who choose science as a major and a faculty experienced in research and the training of students in neuroscience research with special interests in molecular and cellular approaches. The proposed MIRDP student curriculum is built on a core mental health-neuroscience concentration that already exists. The MIRDP faculty and students will be involved with modern neurobiological-immune techniques (receptor binding, neuroendocrine/behavior, neurotransmitter/ modulator identification, image analysis), and will work as well on many levels (molecular, cellular and organismic) concerned with the elucidating neuropeptide mechanisms. The program will provide seminars/lectures and workshops related to ADAMHA areas. The students will have an opportunity to earn entrance into the existing ADAMHA-MARC Program as well as our Society for Neuroscience Chapter. Our program stresses meritorious mental health-drug abuse research as an immediate goal or measure of our activity. The career choices of the students will be broadened, and their expertise and awareness of mental health and related areas will increase. This program offers a strong "wet-lab" foundation to foster mental health and drug abuse interests and build on these areas as career options as well as develop both faculty research and institutional advancement in this area.

拟议的老韦斯特伯里神经科学研究所将增加 纽约州立大学/旧韦斯特伯里学院、教职员工和我们的研究潜力 少数民族本科生。近期的目标将是 为教师提供研究支持，使他们能够获得 R01型补助金，为进一步发展创造环境 学院的研究并增加少数族裔学生的代表性 研究生课程。从长远来看，目标将是增加 从事心理健康和药物滥用职业的少数族裔学生人数 治疗和预防。该学院非常适合开展这项工作 使命，因为它有很高比例的少数族裔学生选择 科学作为一个专业以及在研究和培训方面经验丰富的教师 对分子有特殊兴趣的神经科学研究学生 和细胞方法。拟议的 MIRDP 学生课程建立在 已经存在的核心心理健康-神经科学专业。这 MIRDP 教职员工和学生将参与现代 神经生物免疫技术（受体结合， 神经内分泌/行为、神经递质/调节剂识别、图像 分析），并且在许多层面（分子、细胞和 有机体）与阐明神经肽机制有关。这 计划将提供与 ADAMHA 相关的研讨会/讲座和讲习班 地区。学生将有机会进入 现有的 ADAMHA-MARC 计划以及我们的神经科学学会 章。我们的计划强调有价值的心理健康药物滥用研究 作为我们活动的直接目标或衡量标准。的职业选择 学生的专业知识和心理意识将得到拓宽 健康及相关领域将会增加。该计划提供了强大的 “wet-lab”基金会旨在培养心理健康和药物滥用方面的兴趣 以这些领域为职业选择并培养教师 该领域的研究和机构进步。