权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Catalytic methods for peroxide mediated oxidation

过氧化物介导的氧化的催化方法

基本信息

批准号：
1811694
负责人：
金额：
--
依托单位：
University of Strathclyde
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1811694
关键词：
Catalytic methods peroxide mediated oxidation

项目摘要

The project will involve development of synthetic methodology guided by mechanistic insight of importance to the thematic areas of Healthcare Technologies, Physical Sciences and Manufacturing the Future.We have recently reported a metal-free method for the dihydroxylation of alkenes that proceeds in the presence of both moisture and air (J. Am. Chem. Soc. 2010, 132, 14409). Treatment of an alkene with one equivalent of a malonoyl peroxide (CHCl3; 0.5 M; r.t.; H2O 1 equiv), followed by hydrolysis, gives the corresponding diol in 82-96% isolated yield with syn selectivity (up to 50:1). This represents an effective method for the dihydroxylation of alkenes which has significant advantages over traditional transition-metal catalysed processes and has great potential for development. In order to realise the full potential of this protocol a catalytic procedure must be developed. We therefore wish to undertake a project with the following major goals and objectives:* Develop a novel catalytic cycle for the dihydroxylation of alkenes.* Establish the scope of the process for substituted alkenes.* Characterise the kinetics and mechanism of the catalytic cycle.Successful outcome of this project will deliver a simple, effective and industry relevant catalytic oxidation procedure that proceeds at room temperature in the presence of moisture and air.

该项目将涉及以对医疗保健技术、物理科学和未来制造等主题领域具有重要意义的机械见解为指导的合成方法的开发。我们最近报道了一种在水分和空气存在下进行烯烃二羟基化的无金属方法（J. Am. Chem. Soc. 2010, 132, 14409）。用一当量丙二酰过氧化物（CHCl3；0.5 M；室温；H2O 1 当量）处理烯烃，然后水解，得到相应的二醇，分离收率为 82-96%，顺式选择性（高达 50:1）。这代表了一种有效的烯烃二羟基化方法，与传统过渡金属催化工艺相比具有显着优势，具有巨大的发展潜力。为了充分发挥该协议的潜力，必须开发催化程序。因此，我们希望开展一个具有以下主要目的和目标的项目：* 开发一种用于烯烃二羟基化的新型催化循环。* 确定取代烯烃的工艺范围。* 表征催化循环的动力学和机制。该项目的成功结果将提供一种简单、有效且与行业相关的催化氧化程序，该程序在室温下、有水分和存在的情况下进行。空气。