Understanding the structure and function of the DDR1 juxtamembrane region

盘状结构域受体是细胞外基质蛋白胶原的受体。解除武装、复员和重返社会在发展中发挥重要作用，并有助于人类许多疾病的疾病进展。虽然我们对DDR胞外区与胶原之间的相互作用有了详细的了解，但对于胶原结合如何导致细胞内激酶激活的了解还不是很多。我的实验室发现，DDR受到其细胞内膜旁区域的正向调控。该项目将使用生化和结构方法来研究膜旁区域促进DDR激活的机制。

Discoidin domain receptors (DDRs) are receptors for the extracellular matrix protein collagen. The DDRs play important roles in development and contribute to disease progression of a number of human diseases. While we have detailed understanding of the interactions between the DDR extracellular region with collagen, not much is known about how collagen binding results in intracellular kinase activation. My lab has discovered that the DDRs are positively regulated by their intracellular juxtamembrane regions. This project will use biochemical and structural approaches to investigate the mechanisms whereby juxtamembrane regions promote DDR activation.