Understanding the neurodevelopmental effects of youth tackle football participation
了解青少年参与橄榄球运动对神经发育的影响
基本信息
- 批准号:10742262
- 负责人:
- 金额:$ 65.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAgeAttenuatedBehaviorBenefits and RisksBrainBrain InjuriesChildChildhoodChronic Brain InjuryClinicalCognitionCollaborationsCommunitiesCommunity OutreachCosts and BenefitsCritical IllnessDataDecision MakingDevelopmentEarly DiagnosisEnrollmentEquilibriumEtiologyExhibitsExposure toFundingFutureGoalsHealthImpaired cognitionImpairmentInterventionKnowledgeLong-Term EffectsManufactured footballMeasuresMissionNational Institute of Child Health and Human DevelopmentNatureNeckNervous System TraumaNeurodegenerative DisordersNeurodevelopmental DisorderOhioOutcomeParentsPatientsPerformancePilot ProjectsPlayPoliciesPolicy MakerPreventionProductivityPublic HealthReaction TimeRecording of previous eventsReportingResearchRestRiskRisk FactorsRisk ReductionSeasonsShort-Term MemorySportsStructureTestingTimeVisualWorkYouthadverse childhood eventsattentional controlcognitive functioncognitive testingcollegecommunity engagementcontact sportscritical periodexecutive functionfunctional disabilityhead impacthigh schoolimprovedinstrumentmodifiable riskmultidisciplinarymyelinationneuralneurodevelopmentneurodevelopmental effectneuroimagingneuromuscularneurophysiologypediatric traumapreventprogramswhite matteryouth sports
项目摘要
ABSTRACT
Potential long-term effects of tackle football and other contact sports have created significant public health
concerns about the risk of childhood participation. Considering the retrospective and cross-sectional nature of
prior work, there are critical knowledge gaps regarding the causality of youth tackle football participation and
subsequent clinical outcomes that preclude decision-making at the patient and policy level. Further, modifiable
risk factors (e.g., neuromuscular control) may influence exposure to and thus, outcomes from football-related
neurotrauma, but prevention remains understudied. Here we overcome some of the previous barriers to progress
in this field by acquiring a “true baseline” for athletes before they begin their first season of tackle football and
following them longitudinally across the first year of participation. We received funding from Ohio State’s Chronic
Brain Injury Program and successfully collected pilot data on 50 youth tackle football players (ages 8-12 years);
these data form the basis of our current proposal. Aim 1 will identify risk factors for higher exposure to football-
related neurotrauma. We will measure football-related neurotrauma exposure in first-year youth tackle football
players during all practices and games using instrumented mouthguards. We will use handheld dynamometry to
measure neck strength and will measure neuromuscular control through visual, vestibular, and reaction time
testing. Aim 2 will determine the effects of football-related neurotrauma exposure on neurodevelopment in
children with no previous tackle football exposure. We will enroll children who are registered for, but have not
yet begun participating in youth tackle football, as well as children registered for non-contact sports and children
not playing any sports. Aim 2a will determine short-term changes in cognitive function and brain structure and
function caused by football-related neurotrauma exposure from pre-season to post-season. Aim 2b will
determine longer-term changes across the first year of participation by examining players during the off-season
just prior to the start of the next season. Aim 2c will determine what factors (e.g., football-related neurotrauma
exposure, exposure to adverse childhood events, pre-existing neurodevelopmental disorders) contribute to
differences from typical development. We hypothesize that youth tackle football exposes children to repetitive
neurotrauma during a period of rapid neurodevelopment, resulting in observable cognitive impairments and
structural and functional changes in the brain, most likely in attentional control networks. Our proposal combines
a state-of-the-art approach to determining the effects of football-related neurotrauma on neurodevelopment, a
productive collaboration with youth sports programs in Ohio, community engagement and outreach, and a
multidisciplinary team of experts. The societal and clinical impact of these findings cannot be overstated. In
quantifying football-related neurotrauma exposure (Aim 1) and its effects on neurodevelopment (Aim 2) across
the first year of youth tackle football participation, our expected outcomes will inform community stakeholders
and policy-makers in their appraisal of the cost and benefit of children participating in youth tackle football.
摘要
铲球足球和其他接触性运动的潜在长期影响已经造成了重大的公共健康问题
关注儿童参与的风险。考虑到本报告的回顾性和跨部门性质,
在之前的工作中,关于青少年参与足球比赛的因果关系存在严重的知识差距,
随后的临床结果,排除在病人和政策层面的决策。此外,可修改
风险因素(例如,神经肌肉控制)可能会影响接触足球相关的结果,
神经创伤,但预防仍然研究不足。在这里,我们克服了一些以前的障碍,以取得进展
在这一领域,在运动员开始第一个赛季的铲球足球之前,
在参与的第一年纵向跟踪他们。我们得到了俄亥俄州慢性病研究所的资助
脑损伤计划,并成功收集了50名青少年铲球足球运动员(8-12岁)的试点数据;
这些数据是我们现时建议的基础。目标1将确定更多接触足球的风险因素-
相关神经损伤我们将测量第一年青少年铲球足球相关的神经创伤暴露
球员在所有的练习和比赛中使用仪器护齿。我们将使用手持式测力仪,
测量颈部力量,并将通过视觉、前庭和反应时间测量神经肌肉控制
试验.目的2将确定足球相关的神经创伤暴露对神经发育的影响,
没有接触过橄榄球的孩子。我们将招收已注册但尚未注册的儿童
还没有开始参加青少年铲球足球,以及儿童登记为非接触性运动和儿童
不做任何运动。目标2a将确定认知功能和大脑结构的短期变化,
从赛季前到赛季后,与足球相关的神经创伤暴露所引起的功能。目标2b将
通过在休赛期检查球员来确定第一年的长期变化
就在下个赛季开始之前。目标2c将确定哪些因素(例如,足球相关神经损伤
暴露、暴露于不良童年事件、既存神经发育障碍)有助于
与典型发展的差异。我们假设,青少年铲球足球暴露儿童重复
在快速神经发育期间的神经创伤,导致可观察到的认知障碍,
大脑的结构和功能变化,最有可能是注意力控制网络。我们的建议结合了
一种确定足球相关神经创伤对神经发育影响的最先进方法,
与俄亥俄州的青年体育项目进行了富有成效的合作,社区参与和推广,以及
多学科专家团队。这些发现的社会和临床影响不能被夸大。在
量化足球相关的神经创伤暴露(目标1)及其对神经发育的影响(目标2)
在青少年参与足球运动的第一年,我们的预期成果将告知社区利益相关者
以及政策制定者对儿童参加青少年足球比赛的成本和收益的评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jaclyn B. Caccese其他文献
Cognitive and Behavioral Outcomes in Male and Female NCAA Soccer Athletes across Multiple Years: A CARE Consortium Study
NCAA 男女足球运动员多年来的认知和行为结果:CARE 联盟研究
- DOI:
10.1249/mss.0000000000003063 - 发表时间:
2022 - 期刊:
- 影响因子:4.1
- 作者:
Jaclyn B. Caccese;K. Bryk;Tara Porfido;A. Bretzin;K. Peek;T. Kaminski;A. Kontos;Sara P D Chrisman;M. Putukian;T. Buckley;S. Broglio;T. McAllister;M. McCrea;P. Pasquina;C. Esopenko - 通讯作者:
C. Esopenko
Associations of Collegiate Football Career and Incident Concussion with Players' Health: A Longitudinal Study from the CARE Consortium
- DOI:
10.1007/s40279-025-02234-1 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:9.400
- 作者:
Katherine J. Hunzinger;Jaclyn B. Caccese;Connor A. Law;Rachael M. Wittmer;Thomas A. Buckley;Steven P. Broglio;Thomas W. McAllister;Michael A. McCrea;Paul F. Pasquina;Andrea L. C. Schneider - 通讯作者:
Andrea L. C. Schneider
Female Collegiate Athletes’ Concussion Characteristics and Recovery Patterns: A Report from the NCAA-DoD CARE Consortium
女大学运动员的脑震荡特征和恢复模式:来自 NCAA-DoD CARE 联盟的报告
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:3.8
- 作者:
Landon B. Lempke;Jaclyn B. Caccese;Reid A Syrydiuk;Thomas A Buckley;Sara P D Chrisman;J. Clugston;J. Eckner;Elsa Ermer;Carrie Esopenko;Divya Jain;Louise A. Kelly;Allyssa K. Memmini;Anne E. Mozel;M. Putukian;A. Susmarski;P. Pasquina;M. McCrea;T. McAllister;S. Broglio;Christina L. Master - 通讯作者:
Christina L. Master
Sex Differences in Recovery Trajectories of Assessments for Sport-Related Concussion Among NCAA Athletes: A CARE Consortium Study
- DOI:
10.1007/s40279-023-01982-2 - 发表时间:
2023-12-22 - 期刊:
- 影响因子:9.400
- 作者:
Jaclyn B. Caccese;Christina L. Master;Thomas A. Buckley;Sara P. D. Chrisman;James R. Clugston;James T. Eckner;Elsa Ermer;Stacey Harcum;Tamerah N. Hunt;Divya Jain;Louise A. Kelly;T. Dianne Langford;Landon B. Lempke;Jane McDevitt;Allyssa K. Memmini;Anne E. Mozel;Susan M. Perkins;Margot Putukian;Patricia R. Roby;Adam Susmarski;Steven P. Broglio;Thomas W. McAllister;Michael McCrea;Paul F. Pasquina;Carrie Esopenko - 通讯作者:
Carrie Esopenko
Repetitive subconcussive head impacts and changes in sensory processing for balance control
重复的次脑震荡头部撞击和平衡控制的感觉处理变化
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Jaclyn B. Caccese;F. Santos;E. Anson;T. Buckley;Felipe Yamaguchi;Mariana Gongora;J. Jeka - 通讯作者:
J. Jeka
Jaclyn B. Caccese的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
- 批准号:
24K13490 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
- 批准号:
EP/Z00022X/1 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
- 批准号:
MR/Y003365/1 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
- 批准号:
AH/Y007549/1 - 财政年份:2024
- 资助金额:
$ 65.27万 - 项目类别:
Research Grant