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Confocal Microscope

共焦显微镜

基本信息

批准号：
6440353
负责人：
John P Welsh
金额：
$ 50万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-05-01 至 2003-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6440353
关键词：
biomedical equipment purchase confocal scanning microscopy immunocytochemistry neuroanatomy neurophysiology

项目摘要

A laser scanning confocal microscope system is requested for the Neurological Sciences Institute (NSI) of Oregon Health Sciences University in support of numerous NIH peer-reviewed grants. The vendor selected is Zeiss, whose latest technology, the Laser Scanning Microscope-510 with Non Linear Optics (LSM-510 NLO), is a state-of- the-art instrument that allows simultaneous multi-photon and single- photon excitation of biological tissue for the highest-sensitivity subcellular imaging and analysis of anatomical structure and physiological processes. The NSI will provide substantial support in the way of establishing a central core-facility for the instrument, cost- sharing, training, and a life-time maintenance and service contract. A group of 5 "major users" with expertise in immunohistochemistry, fluorescence microscopy, neuroanatomy, and in vitro neurophysiology will employ 75% of the instrument's time. The balance of the instrument's time will be occupied by 8 additional faculty of the NSI. Altogether, the instrument will be used in support of 19 active NIH peer- reviewed awards from 9 different NIH institutes. The NSI is a newly formed group of 22 senior investigators that have been recruited from academic centers throughout the world that is housed in a brand new (February, 2001), 66,000 square foot, state-of-the-art building on the West Campus of Oregon Health Science University. The addition of a Zeiss LSM-510 NLO will make available to the newly assembled group essential capabilities in functional microscopy of subcellular processes.

俄勒冈州健康科学大学的神经科学研究所（NSI）需要激光扫描共聚焦显微镜系统，以支持许多NIH同行评审的赠款。选择的供应商是蔡司，其最新技术，激光扫描显微镜-510与非线性光学（LSM-510 NLO），是一个国家的最先进的仪器，允许同时多光子和单光子激发生物组织的最高灵敏度亚细胞成像和分析的解剖结构和生理过程。NSI将通过建立仪器中央核心设施、成本分摊、培训以及终身维护和服务合同等方式提供实质性支持。一组5个“主要用户”，具有免疫组织化学、荧光显微镜、神经解剖学和体外神经生理学方面的专业知识，将占用仪器75%的时间。该仪器的时间的平衡将由NSI的另外8个教师占用。总之，该工具将用于支持来自9个不同NIH研究所的19个活跃的NIH同行评审奖项。NSI是一个由22名高级研究人员组成的新成立的小组，他们是从世界各地的学术中心招募来的，位于俄勒冈州健康科学大学西校区的一座全新（2001年2月）的66，000平方英尺的最先进建筑内。蔡司LSM-510 NLO的加入将使新组装的小组在亚细胞过程的功能显微镜中具有必要的能力。