CENTRAL RHYTHMOGENESIS AND BEHAVIOR

中枢节律发生和行为

• 批准号: 6165477
• 负责人: John P Welsh
• 金额: $ 26.29万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-03-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6165477
• 关键词: behavioral /social science research tag; body movement; brain electrical activity; brain mapping; central neural pathway /tract; cerebellar Purkinje cell; cerebellum; conditioning; electromyography; ethology; laboratory rat; limb movement; microelectrodes; mossy fiber; neuromuscular function; neurotoxins; olivary body; stereotaxic techniques; tongue; video recording system

DESCRIPTION (Adapted from the Abstract): The purpose of this project is to elucidate the function and significance of the robust electrical rhythmicity of the neurons in the inferior olive and their relation to the temporal and spatial organization of skilled movement. In this experiments, the Principal Investigator will employ multiple-microelectrode recordings of Purkinje cell complex spike activity in vivo while rats perform skilled movements with their oro-facial and limb muscles. The central working hypothesis of this project is that the muscle synergies required for coordinated movement of multiple limbs depend upon the rhythmic activity of the highly parallel projection from the inferior to the cerebellum. This activity physically and rhythmically modulates motor systems. Indeed, that damage to the inferior in humans animals permanently destroys the temporal and spatial structure of skilled movement is firmly established. Using highly controlled experimental conditions with rats, the Investigator will address the following questions: Does the olivocerebellar system organize a forepaw-tongue movement synergy? If so, how? Does the olivocerebellar system temporally organize a spatially-guided movement produced by bilateral musculature? If so, how? What relationship do the two major afferent systems of the cerebellum, the climbing and the mossy fibers, have in organizing movement? Does uncontrolled rhythmic activity within the inferior olive drive pathologically rhythmic movements, such as those seen during a myoclonic seizure?

描述（改编自摘要）：本项目的目的是 阐明了强电节律性的作用和意义 下橄榄核内神经元的分布及其与颞叶、 熟练动作的空间组织。 在这个实验中， 主要研究者将采用多微电极记录 浦肯野细胞复合体在体内的尖峰活动，而大鼠执行熟练的 面部和四肢肌肉的运动。 中央工作 该项目的假设是，肌肉协同作用所需的 多个肢体的协调运动取决于 从小脑下部到小脑的高度平行的突起。 这 活动在身体上和有节奏地调节运动系统。 的确， 对人类和动物中的低等动物的伤害永久地破坏了颞叶 熟练动作的空间结构牢固确立。 使用 在高度受控的大鼠实验条件下，研究者将 解决以下问题：橄榄小脑系统是否组织 前爪-舌头运动的协同作用？ 如果是，如何做到？ 橄榄小脑 系统在时间上组织由双侧运动产生空间引导运动 肌肉组织？ 如果是，如何做到？ 这两个主要的传入神经元 小脑的系统，攀爬纤维和苔藓纤维， 组织运动？ 在大脑中不受控制的节律活动 下橄榄核驱动病理性节律运动， 在肌阵挛发作期间