Small Molecule X-Ray Diffraction Instrumentation

小分子 X 射线衍射仪器

• 批准号: 6440796
• 负责人: ANDREW D MESECAR
• 金额: $ 27.38万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6440796
• 关键词: X ray crystallography; biomedical equipment purchase; copper; molybdenum

A state-of-the-art CCD (charge-coupled-device) area detector with sealed-tube x-ray generator and low-temperature cooling device will be purchased and used too collect x-ray diffraction data from single crystals with Mo and Cu radiation. This will be will be used to establish a multi- user, small molecule, single-crystal, x-ray diffraction facility in the College of Pharmacy at the University of Illinois at Chicago (UIC). This facility will principally support research in at least 9 major laboratories including two NIH program grants and one NIH center. Approximately 80% of the instrument will be utilized by NIH-funded researchers, and the remaining time will be used by other researchers on the UIC campus and the Chicago area. In addition, the instrument hardware, software, and computing resources will be used to augment courses in Medicinal Chemistry, Pharmacognosy, Chemistry and Pharmaceutical Biotechnology. This instrument will replace the slow, aging, and somewhat unreliable CAD4 diffractometer that is housed on the eat campus near Chemistry. To date, most of the structures solved for UIC faculty research projects have occurred through off-campus collaborations or through off-campus data collection, when available. This instrument will be located on the west medical campus immediately adjacent to the UIC/RRC MacroMolecular Diffraction Facility; this increases the accessibility of the instrument for both research and training. Access to the instrument by new users on and off campus will be assured through the administrative oversight of an advisory committee and the Research Resources Center (RRC). The RRC is a centralized campus center and instrumentation facility that has been in operation for over fifty years. The RRC will handle maintenance of the instrumentation in collaboration with the director of the facility and the advisory committee. Dr. Santarsiero has been hired as the director of the new facility. His primary function is to oversee operations and maintenance of this service facility through contact with RRC, the Dean of the College of Pharmacy, the advisory committee and the research faculty. The mechanism of sample submission will be established by the advisory committee and will include hands-on use by graduate students and postdoctoral researchers. As outlined, this facility will substantially benefit several research programs and NIH program grants and centers. The much increased need for such instrumentation reflects the growing importance of structural chemistry and structural biology as a component in research and teaching at the University of Illinois at Chicago, as well as several new initiatives in the areas of structural biology and chemistry at UIC.

购买最先进的CCD（电荷耦合器件）区域探测器，配备密封管x射线发生器和低温冷却装置，用于收集Mo和Cu辐射单晶的x射线衍射数据。这将被用于在芝加哥伊利诺伊大学药学院建立一个多用户、小分子、单晶的x射线衍射设备。该设施将主要支持至少9个主要实验室的研究，包括两个NIH项目拨款和一个NIH中心。大约80%的仪器将由美国国立卫生研究院资助的研究人员使用，其余时间将由UIC校园和芝加哥地区的其他研究人员使用。此外，仪器的硬件、软件和计算资源将用于增加药物化学、生药学、化学和制药生物技术的课程。该仪器将取代位于校区化学附近的缓慢、老化且不太可靠的CAD4衍射仪。迄今为止，UIC教师研究项目解决的大多数结构都是通过校外合作或校外数据收集（如果有的话）完成的。该仪器将位于西医学院，紧邻UIC/RRC大分子衍射设施；这增加了该仪器在研究和培训方面的可利用性。通过咨询委员会和研究资源中心（RRC）的行政监督，将确保校园内外的新用户使用该仪器。RRC是一个集中式的校园中心和仪器设备，已经运行了50多年。RRC将与设施主管和咨询委员会合作处理仪器的维护工作。桑塔西罗医生被聘为新医院的主任。他的主要职能是通过与RRC、药学院院长、咨询委员会和研究人员的联系，监督该服务设施的运营和维护。咨询委员会将建立样本提交机制，并由研究生和博士后研究人员实际使用。如上所述，该设施将大大有利于几个研究项目和NIH项目赠款和中心。对这类仪器的需求大幅增加，反映了结构化学和结构生物学在伊利诺伊大学芝加哥分校的研究和教学中日益重要，也反映了伊利诺伊大学芝加哥分校在结构生物学和化学领域的一些新举措。