Small Molecule X-Ray Diffraction Instrumentation

将购买最先进的电荷耦合器件(电荷耦合器件)面阵探测器，带有密封管X射线发生器和低温冷却装置，用于采集单晶在钼和铜辐射下的X射线衍射数据。这将被用来在伊利诺伊大学芝加哥分校(UIC)的药学院建立一个多用户、小分子、单晶、X射线衍射设施。该设施将主要支持至少9个主要实验室的研究，包括两个NIH项目拨款和一个NIH中心。大约80%的仪器将被NIH资助的研究人员使用，其余的时间将被UIC校园和芝加哥地区的其他研究人员使用。此外，仪器硬件、软件和计算资源将用于增加药物化学、生药学、化学和药物生物技术课程。这台仪器将取代安装在EAT校园化学附近的缓慢、老化和有点不可靠的CAD4衍射仪。到目前为止，大多数为UIC教员研究项目解决的结构都是通过校外合作或通过校外数据收集(如果有)实现的。该仪器将设在西部医学院园区，紧挨着UIC/RRC大分子衍射设施；这增加了仪器用于研究和培训的可及性。校园内外的新用户将通过一个咨询委员会和研究资源中心(RRC)的行政监督来确保获得该仪器。RRC是一个已经运行了50多年的集中式校园中心和仪器设施。RRC将与设施主任和咨询委员会合作处理仪器的维护工作。桑塔西罗博士已被聘为新设施的负责人。他的主要职能是通过与RRC、药学院院长、咨询委员会和研究人员的联系，监督这一服务设施的运营和维护。样本提交机制将由咨询委员会建立，并将包括研究生和博士后研究人员的动手使用。如上所述，这一设施将使几个研究计划和NIH计划拨款和中心大大受益。对这类仪器的需求大大增加，反映了结构化学和结构生物学作为伊利诺伊大学芝加哥分校研究和教学组成部分的重要性与日俱增，以及UIC在结构生物学和化学领域的几项新举措。

A state-of-the-art CCD (charge-coupled-device) area detector with sealed-tube x-ray generator and low-temperature cooling device will be purchased and used too collect x-ray diffraction data from single crystals with Mo and Cu radiation. This will be will be used to establish a multi- user, small molecule, single-crystal, x-ray diffraction facility in the College of Pharmacy at the University of Illinois at Chicago (UIC). This facility will principally support research in at least 9 major laboratories including two NIH program grants and one NIH center. Approximately 80% of the instrument will be utilized by NIH-funded researchers, and the remaining time will be used by other researchers on the UIC campus and the Chicago area. In addition, the instrument hardware, software, and computing resources will be used to augment courses in Medicinal Chemistry, Pharmacognosy, Chemistry and Pharmaceutical Biotechnology. This instrument will replace the slow, aging, and somewhat unreliable CAD4 diffractometer that is housed on the eat campus near Chemistry. To date, most of the structures solved for UIC faculty research projects have occurred through off-campus collaborations or through off-campus data collection, when available. This instrument will be located on the west medical campus immediately adjacent to the UIC/RRC MacroMolecular Diffraction Facility; this increases the accessibility of the instrument for both research and training. Access to the instrument by new users on and off campus will be assured through the administrative oversight of an advisory committee and the Research Resources Center (RRC). The RRC is a centralized campus center and instrumentation facility that has been in operation for over fifty years. The RRC will handle maintenance of the instrumentation in collaboration with the director of the facility and the advisory committee. Dr. Santarsiero has been hired as the director of the new facility. His primary function is to oversee operations and maintenance of this service facility through contact with RRC, the Dean of the College of Pharmacy, the advisory committee and the research faculty. The mechanism of sample submission will be established by the advisory committee and will include hands-on use by graduate students and postdoctoral researchers. As outlined, this facility will substantially benefit several research programs and NIH program grants and centers. The much increased need for such instrumentation reflects the growing importance of structural chemistry and structural biology as a component in research and teaching at the University of Illinois at Chicago, as well as several new initiatives in the areas of structural biology and chemistry at UIC.