Digital Tecnai 12 Transmission Electron Microscope

描述（由申请人提供）：这是一个申请，要求一个州 最先进的数字透射电子显微镜。具体而言，资金用于 购买FEI Tecnai 12 Twin透射电子显微镜和Gatan 794 正在申请用于数字图像采集的多扫描相机。该状态 最先进的仪器将被纳入电子显微镜核心 结缔组织研究实验室。这将提供对组的访问 高效和互动的调查人员，需要访问 高质量透射电子显微镜。Tecnai 12变速箱 电子显微镜将支持各种正在进行的研究项目， 利用现有的专门知识，扩大结构研究的范围 这是可以实现的。增加这一文书将有助于 杰斐逊的超微结构研究在这个过程中产生了新的项目， 和协作互动。杰斐逊医学院有一大群 设立调查员，处理与下列方面有关的广泛问题： 结缔组织生物学通过研究确定了八个主要用户 项目涉及：细胞外基质组装和结缔组织 发展;皮肤宿主与移植物疾病的病理学; 蛋白聚糖在癌症和发展中的结构和功能 细胞外基质大分子/复合物;大分子相互作用和 组织功能;皮肤/结缔组织疾病小鼠模型;生物学 皮肤基底膜区的结构和功能 弹性纤维在发展和疾病;和发展的基因 治疗皮肤和结缔组织疾病。他们的每一项研究 程序将受益于调制解调器的可用性，研究 透射电子显微镜

DESCRIPTION (provided by applicant): This is an application requesting a state of the art digital transmission electron microscope. Specifically, the funds to purchase a FEI Tecnai 12 Twin Transmission Electron Microscope with a Gatan 794 Multiscan Camera for digital image acquisition are being requested. This state of the art instrument will be incorporated into a Electron Microscopy Core Laboratory for Connective Tissue Research. This will provide access to a group of highly productive and interactive investigators that require access to a high quality transmission electron microscope. The Tecnai 12 transmission electron microscope will support a variety of ongoing research projects, take advantage of available expertise and broaden the scope of structural studies that can be accomplished. The addition of this instrument will facilitate ultrastructural studies at Jefferson generating, in the process, new projects and collaborative interactions. Jefferson Medical College has a large group of established investigators addressing a broad range of questions related to connective tissue biology. Eight major users are identified with research projects addressing: extracellular matrix assembly and connective tissue development; pathology of cutaneous host vs graft disease; biology of proteoglycans in cancer and development; structure and function of extracellular matrix macromolecules/complexes; macromolecular interactions and tissue function; mouse models of cutaneous/connective tissue disease; biology and pathology of the cutaneous basement membrane zone; structure and function of the elastic fiber in development and disease; and development of gene therapy for cutaneous and connective tissue diseases. Each of their research programs would benefit significantly from the availability of a modem, research grade transmission electron microscope.