权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

THEORETICAL STUDIES IN ECOLOGICAL & POPULATION GENETICS

生态学理论研究

基本信息

批准号：
6385781
负责人：
WYATT W. ANDERSON
金额：
$ 19.18万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-01-01 至 2005-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6385781
关键词：
animal data animal population genetics biochemical evolution ecology experimental designs gene frequency genetic markers genetic models human data human population genetics mathematical model model design /development natural selections statistics /biometry

项目摘要

Multi-genomic data provide an unprecedented opportunity to study many critical evolutionary processes in human and other populations. A particularly striking example is provided by the increasing use of joint nuclear-cytoplasmic data, where an individual's nuclear genes are inherited through both parents, while their cytoplasmically-housed genes, such as those in their mitochondria, are usually inherited solely through the mother. As a result of this asymmetrical inheritance, a population's joint nuclear-cytoplasmic makeup encodes invaluable information about many important processes that are not accessible by traditional means. Such data provide, for instance, the first effective way to study the distinctive patterns of assortative mating, selection, and migration within zones of genetic admixture between two populations, as well as the many gender-specific processes that shape the evolution of human and other animal populations. However, much of this vital biological information remains untapped due to the lack of adequate theory. The major long-term goal of this research is to develop the mathematical and statistical frameworks needed to fully exploit the immense evolutionary value of joint cytonuclear data. One specific aim is to identify the best method for detecting and estimating differential gene flow by males and females, which will allow unprecedented insight into human migrations. This will be achieved by developing a series of theoretical models to assess the utility of recent data involving novel combinations of cytoplasmic, autosomal and sex-linked marker. A second major goal is to provide the first formal cytonuclear guidelines for inferring the possible evolutionary processes in spatially structured populations, and the potential causes of the differential introgression often shown by autosomal, sex-linked, and cytoplasmic markers across such regions. The final major aim is to develop theory to understand the evolutionary implications of intriguing new forms of cytonuclear selection, including those in human mitochondrial diseases, where nuclear genes can trigger the mitochondrial mutations associated with the disease. Together, the results will allow empirical researchers to exploit standard cytonuclear systems with autosomal nuclear markers in exciting new ways, as well as to extract the unprecedented evolutionary information provided by cytonuclear systems with sex-linked markers. In addition, the general cytonuclear framework developed here has broad applicability to many other important biological systems, ranging from the evolution of mobile element suppressors to the coevolution of host-pathogen systems.

多基因组数据为研究人类和其他种群的许多关键进化过程提供了前所未有的机会。一个特别引人注目的例子是越来越多地使用核质联合数据，其中一个人的核基因是通过父母双方遗传的，而他们细胞质中的基因，如线粒体中的基因，通常只通过母亲遗传。作为这种不对称遗传的结果，一个群体的联合核质构成编码了关于许多重要过程的宝贵信息，这些信息是传统方法无法获得的。例如，这些数据提供了第一个有效的方法来研究两个种群之间遗传混合区域内的分类交配、选择和迁徙的独特模式，以及塑造人类和其他动物种群进化的许多性别特有的过程。然而，由于缺乏足够的理论，许多重要的生物学信息仍然没有被利用。这项研究的主要长期目标是制定充分利用联合细胞核数据的巨大进化价值所需的数学和统计框架。一个具体的目标是确定检测和估计男性和女性差异基因流动的最佳方法，这将使人们能够前所未有地洞察人类的迁徙。这将通过开发一系列理论模型来评估最新数据的实用性，这些数据涉及细胞质、常染色体和性别连锁标记的新组合。第二个主要目标是提供第一个正式的细胞核指南，用于推断空间结构种群中可能的进化过程，以及这些区域中常染色体、性别连锁和细胞质标记经常显示的差异导入的潜在原因。最后一个主要目标是开发理论，以了解耐人寻味的新形式的细胞核选择的进化含义，包括那些在人类线粒体疾病中的选择，其中核基因可以触发与疾病相关的线粒体突变。总而言之，这些结果将使经验研究人员能够以令人兴奋的新方式开发具有常染色体核标记的标准细胞核系统，以及提取具有性别连锁标记的细胞核系统提供的前所未有的进化信息。此外，本文开发的通用细胞核框架对许多其他重要的生物系统具有广泛的适用性，从移动元件抑制子的进化到宿主-病原体系统的共同进化。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cytonuclear models of epistatic mating with backcrossing and selection.

回交和选择的上位交配的细胞核模型。

DOI：
10.1016/j.tpb.2004.12.001
发表时间：
2005
期刊：
Theoretical population biology.
影响因子：
0
作者：
Dakin,ElizabethE;Asmussen,MarjorieA
通讯作者：
Asmussen,MarjorieA

The effects of pollen and seed migration on nuclear-dicytoplasmic systems. I. Nonrandom associations and equilibrium structure with both maternal and paternal cytoplasmic inheritance.

花粉和种子迁移对核双细胞质系统的影响。

DOI：
10.1093/genetics/155.2.813
发表时间：
2000
期刊：
Genetics
影响因子：
3.3
作者：
Asmussen,MA;Orive,ME
通讯作者：
Orive,ME

Cytonuclear theory for haplodiploid species and X-linked genes. I. Hardy-Weinberg dynamics and continent-island, hybrid zone models.

单倍二倍体物种和 X 连锁基因的细胞核理论。

DOI：
10.1093/genetics/147.1.321
发表时间：
1997
期刊：
Genetics
影响因子：
3.3
作者：
Goodisman,MA;Asmussen,MA
通讯作者：
Asmussen,MA

Sexual isolation between North American and Bogota strains of Drosophila pseudoobscura.

北美和波哥大果蝇品系之间的性隔离。

DOI：
10.1007/s10519-011-9517-7
发表时间：
2012
期刊：
Behavior genetics
影响因子：
2.6
作者：
Kim,Yong-Kyu;Ruiz-Garcia,Manuel;Alvarez,Diana;Phillips,DennisR;Anderson,WyattW
通讯作者：
Anderson,WyattW

Symbiont survival and host-symbiont disequilibria under differential vertical transmission.

差异垂直传播下的共生体存活和宿主-共生体不平衡。