CANCER GENETICS

癌症遗传学

• 批准号: 6501412
• 负责人: Richard D Kolodner
• 金额: $ 18.37万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-21 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6501412
• 关键词: animal genetic material tag; brca gene; gene induction /repression; gene mutation; laboratory mouse; linkage mapping; microarray technology; neoplasm /cancer genetics; oncogenes

The Cancer Genetics Program consists of 12 Participating Members, representing total peer-reviewed funding of $5.1 Million in annual direct costs (7.3 Million in total costs). During the last two years, its Members generated a total of 106-cancer-relevant peer-reviewed publications, 7% of which were intra- and inter-programmatic collaborations. The Cancer Genetics Program is focused on using classical and molecular genetics in the study of cancer, both for understanding the mechanistic basis of the disease and for developing therapeutic interventions. The information coming onstream from Human Genome Project and the availability of tools for use in mutation detection, linkage analysis, positional cloning and candidate gene analysis have facilitated the gene discovery process. This is resulting in the continuing identification of genetic abnormalities involved in the development of various types of cancer. Additionally, the ready availability of experimental methods for the genetic modification of various types of cancer. Additionally, the ready availability of experimental methods for the genetic modification of both mouse and human cells have allowed investigators to study the significance and functional implications of these newly recognized abnormalities for the development and treatment of cancer directly in mammalian systems. Rapid progress in understanding model organisms like yeast, De. Melanogaster, X laevis and C. elegans, coupled with the realization that many molecular pathways that are important in the development of cancer in higher species and mammalian cells are conserved in model organisms, has led to the productive introduction of studies of such organisms into cancer research. Integrated application of these different but complementary approaches to mammalian genetics unify and accelerate our understanding of the interlocking disturbances in the structural and regulatory components of the genome which characterize the onset of neoplasia. To take advantage of these developments and bring them to bear on the cancer research program at UCSD, the Cancer Genetics Program has put emphasis on studying (1) Cancer-relevant Model Systems; (2) Mouse Cancer Genetics; (3) Mammalian Cancer Genetics and; (4) Clinical Cancer Genetics.

癌症遗传学计划由12个参与成员组成，代表年度直接费用510万美元（总费用730万美元）的同行评审资金总额。在过去两年中，其成员共产生了106篇癌症相关的同行评审出版物，其中7%是计划内和计划间合作。癌症遗传学计划专注于在癌症研究中使用经典和分子遗传学，以了解疾病的机制基础和开发治疗干预措施。人类基因组计划提供的信息以及用于突变检测、连锁分析、定位克隆和候选基因分析的工具的可用性促进了基因发现过程。这导致了对参与各种癌症发展的遗传异常的持续鉴定。此外，各种类型癌症的遗传修饰的实验方法的现成可用性。此外，小鼠和人类细胞遗传修饰的实验方法的现成可用性使研究人员能够研究这些新发现的异常对哺乳动物系统中癌症的发展和治疗的意义和功能影响。在理解酵母等模式生物方面的快速进展，De。Melanogaster、X laevis和C. elegans，加上认识到许多在高等物种和哺乳动物细胞中癌症发展中重要的分子途径在模式生物中是保守的，导致了将对这些生物的研究富有成效地引入癌症研究。综合应用这些不同的，但互补的方法，哺乳动物遗传学统一和加速我们的理解联锁干扰的结构和调控的基因组特征的肿瘤的发病。为了利用这些发展，并使他们承担癌症研究计划在加州大学圣地亚哥分校，癌症遗传学计划已把重点放在研究（1）癌症相关的模型系统;（2）小鼠癌症遗传学;（3）哺乳动物癌症遗传学和;（4）临床癌症遗传学。