MINORITY PREDOCTORAL FELLOWSHIP--NIGMS

本文提出的研究目标是评估和量化当能够氢键的基团（例如OH， NH2， COOH）被化学结合到聚合物结构中时，坚硬的生物可降解聚合物微球与活组织之间的粘合相互作用强度的任何变化。研究表明，足够数量的氢键官能团可以增强水凝胶和其他亲水性聚合物以及硬质生物可降解热塑性聚合物的粘合相互作用。

The goal of the research proposed here is to evaluate and quantify any changes resulting in the strength of the adhesive interactions between hard bioadhesive erodible polymer microspheres and living tissue when groups capable of Hydrogen bonding (e.g. OH, NH2, COOH) are chemically incorporated into the structure of the polymers. It has been shown that sufficient quantities of functional groups capable of Hydrogen bonding can lead to enhanced adhesive interactions for both hydrogels and other hydrophilic polymers and hard bioerodible thermoplastic polymers.