MINORITY PREDOCTORAL FELLOWSHIP--NIGMS

少数族裔博士前奖学金

• 批准号: 6525562
• 负责人: JEREL A BANKS
• 金额: $ 3.95万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6525562
• 关键词: adhesions; bioengineering /biomedical engineering; chemical synthesis; gel; hydrogen bond; hydropathy; hydroxyl group; insulin; microcapsule; polymers; slow release drug

The goal of the research proposed here is to evaluate and quantify any changes resulting in the strength of the adhesive interactions between hard bioadhesive erodible polymer microspheres and living tissue when groups capable of Hydrogen bonding (e.g. OH, NH2, COOH) are chemically incorporated into the structure of the polymers. It has been shown that sufficient quantities of functional groups capable of Hydrogen bonding can lead to enhanced adhesive interactions for both hydrogels and other hydrophilic polymers and hard bioerodible thermoplastic polymers.

本文提出的研究目标是评估和量化当能够氢键合的基团（例如OH，NH2，COOH）化学结合到聚合物结构中时，硬生物粘附性可侵蚀聚合物微球和活组织之间的粘附相互作用强度的任何变化。 已经表明，足够量的能够氢键键合的官能团可以导致水凝胶和其它亲水性聚合物以及硬的生物可蚀性热塑性聚合物两者的增强的粘合剂相互作用。