MINORITY PREDOCTORAL FELLOWSHIP--NIGMS

少数族裔博士前奖学金

• 批准号: 6650258
• 负责人: JEREL A BANKS
• 金额: $ 4.13万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6650258
• 关键词: adhesions; bioengineering /biomedical engineering; chemical synthesis; gel; hydrogen bond; hydropathy; hydroxyl group; insulin; microcapsule; polymers; slow release drug

The goal of the research proposed here is to evaluate and quantify any changes resulting in the strength of the adhesive interactions between hard bioadhesive erodible polymer microspheres and living tissue when groups capable of Hydrogen bonding (e.g. OH, NH2, COOH) are chemically incorporated into the structure of the polymers. It has been shown that sufficient quantities of functional groups capable of Hydrogen bonding can lead to enhanced adhesive interactions for both hydrogels and other hydrophilic polymers and hard bioerodible thermoplastic polymers.

本文提出的研究目标是评估和量化当能够形成氢键的基团（例如 OH、NH2、COOH）以化学方式结合到聚合物结构中时，硬质生物粘附易蚀聚合物微球与活体组织之间的粘附相互作用强度发生的任何变化。 已经表明，足够量的能够形成氢键的官能团可以增强水凝胶和其他亲水性聚合物以及硬质可生物侵蚀的热塑性聚合物的粘合相互作用。