Unterstanding the interaction of DNA nanopores with lipid bilayers

化学是重建用于生物医学应用的生物大分子结构的合成版本的关键。该项目的目的是用DNA合成膜孔和通道，以实现生物传感、靶向细胞杀伤和合成生物学的前所未有的分子控制（Science 352, 890-891(2016)）。人工合成的DNA纳米孔模仿生物行为并插入到膜中已经引起了相当大的科学兴趣。最近，DNA孔被描述为选择性地杀死细菌。该项目将确定相互作用的分子决定因素，以获得更基本的理解。这一见解将被用于开发新的抗菌方法。

Chemistry is key to re-create synthetic versions of bio-macromolecular structures that are engineered for biomedical applications. The aim of this project is to generate synthetic versions of membrane pores and channels with DNA to achieve unprecedented molecular control for biosensing, targeted cell killing, and synthetic biology (Science 352, 890-891 (2016)). Synthetic DNA nanopores that mimic biological behaviour and insert into membranes have attracted considerable scientific interest. Recently, DNA pores have been described that selectively kill bacteria. This project will determine the molecular determinants of the interaction to obtain a more fundamental understanding. The insight will be exploited to develop new antibacterial approaches.