Unterstanding the interaction of DNA nanopores with lipid bilayers

了解 DNA 纳米孔与脂质双层的相互作用

• 批准号: 1849570
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1849570
• 关键词: Unterstanding; interaction; DNA; nanopores; lipid

Chemistry is key to re-create synthetic versions of bio-macromolecular structures that are engineered for biomedical applications. The aim of this project is to generate synthetic versions of membrane pores and channels with DNA to achieve unprecedented molecular control for biosensing, targeted cell killing, and synthetic biology (Science 352, 890-891 (2016)). Synthetic DNA nanopores that mimic biological behaviour and insert into membranes have attracted considerable scientific interest. Recently, DNA pores have been described that selectively kill bacteria. This project will determine the molecular determinants of the interaction to obtain a more fundamental understanding. The insight will be exploited to develop new antibacterial approaches.

化学是重新创造生物大分子结构的合成版本的关键，这些结构是为生物医学应用而设计的。该项目的目的是用DNA生成膜孔和通道的合成版本，以实现生物传感，靶向细胞杀伤和合成生物学的前所未有的分子控制（Science 352，890-891（2016））。模拟生物行为并插入膜中的合成DNA纳米孔吸引了相当大的科学兴趣。最近，DNA孔已经被描述为选择性地杀死细菌。这个项目将确定相互作用的分子决定因素，以获得更基本的理解。这一发现将被用于开发新的抗菌方法。