Unterstanding the interaction of DNA nanopores with lipid bilayers

化学是重新创造生物大分子结构的合成版本的关键，这些结构是为生物医学应用而设计的。该项目的目的是用DNA产生膜孔和通道的合成版本，以实现生物传感、靶向细胞杀伤和合成生物学的前所未有的分子控制(科学352,890-891(2016))。模拟生物行为并将其插入膜中的合成DNA纳米孔已经引起了相当大的科学兴趣。最近，DNA小孔被描述为选择性地杀死细菌。这个项目将确定相互作用的分子决定因素，以获得更基本的了解。这一洞察力将被用来开发新的抗菌方法。

Chemistry is key to re-create synthetic versions of bio-macromolecular structures that are engineered for biomedical applications. The aim of this project is to generate synthetic versions of membrane pores and channels with DNA to achieve unprecedented molecular control for biosensing, targeted cell killing, and synthetic biology (Science 352, 890-891 (2016)). Synthetic DNA nanopores that mimic biological behaviour and insert into membranes have attracted considerable scientific interest. Recently, DNA pores have been described that selectively kill bacteria. This project will determine the molecular determinants of the interaction to obtain a more fundamental understanding. The insight will be exploited to develop new antibacterial approaches.