CELLULAR AND MOLECULAR STUDIES ON ANNELID REGENERATION

环节动物再生的细胞和分子研究

• 批准号: 6329602
• 负责人: ALEXANDRA E BELY
• 金额: $ 3.48万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-11-16 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6329602
• 关键词: Annelida; embryogenesis; regeneration

The ability to heal wounds and regenerate lost body parts is of fundamental importance to many animals. Because regeneration and embryogenesis share a common developmental endpoint, it has been suggested that regeneration may in part re-deploy embryonic developmental processes. Many annelid worms have extensive regenerative abilities and experimentally tractable embryos, providing an excellent opportunity to explore the relationships between regenerative and embryonic development. The primary objective of this proposal is to investigate the relationship, at both the cellular and molecular levels, between regeneration and embryogenesis in the annelid Tubifex. Studies will focus on the development of segments, the fundamental body units of annelids, with particular attention to the nervous system. The three specific aims of the project are: 1) to determine whether cell lineage contributions in regenerated segments are the same as those in embryonically produced segments; 2) to determine whether embryonically produced segments made aberrant through teloblast ablation can produce normal segments through regeneration; 3) to characterize and compare the molecular processes of segment formation during regeneration and embryogenesis.

治愈伤口和再生失去的身体部位的能力对许多动物来说是至关重要的。因为再生和胚胎发生共享一个共同的发育终点，所以有人认为再生可能在一定程度上重新部署了胚胎发育过程。许多环节动物具有广泛的再生能力和实验上容易驯化的胚胎，这为探索再生和胚胎发育之间的关系提供了一个极好的机会。这项建议的主要目的是在细胞和分子水平上研究环节动物的再生和胚胎发生之间的关系。研究重点将放在环节动物的基本身体单位节段的发育上，并特别关注神经系统。该项目的三个具体目标是：1)确定再生片段中的细胞谱系贡献是否与胚胎产生的片段中的细胞谱系贡献相同；2)确定通过端粒细胞消融而变得异常的胚胎产生的片段是否能够通过再生产生正常的片段；3)表征和比较再生和胚胎发生过程中片段形成的分子过程。