ROLE OF MORPHOGENETIC PROTEINS IN EMBRYOGENESIS AND TISSUE REGENERATION

在过去的一年里，莫斯博士出版了一本小说的描述， 生长因子，抗背化形态发生蛋白（Anti-Dorsalizing Morphogenetic Protein，ARAP 1）， 在发育过程中对身体轴形成的深刻控制， 脊椎动物这种蛋白质可以提供重要的调控， 神经系统发育专利中包含的主要权利要求 本申请涉及三种其他基因（软骨衍生的基因）。 形态发生蛋白质）已被允许，七个主要的生物技术 公司已经申请了许可证。其中两种蛋白质是特异性的 在过去的一年里， 软骨形成和成骨活性。因此，他们领导着 骨和关节修复临床应用的候选人，以及 自体细胞的操作。描述自体细胞的作用的初步研究 成骨蛋白-1在脊椎动物早期发育中的作用已经完成， 提交出版。突出的发现是， 因子是腹侧衍生物的强大诱导物;最引人注目的 这种效果是显著诱导血液组织。 另一个基因，Frzb， 最初从哺乳动物关节软骨中分离出来， 与NIDR的Frank Luyten合作，已被证明是一种分泌型生长因子。 实验室最近的实验表明， 可以诱导肌肉和神经组织的形成，也参与 在脊椎动物体轴的形成中。此外，它 似乎作为Wnt生长因子的可溶性抑制剂， 功能测定预计这一因素的专利申请 最后，一种用于纯化信号的改进方法， 发表了转导酶腺苷酸环化酶。

During the past year, Dr. Moos has published a description of a novel growth factor, Anti-Dorsalizing Morphogenetic Protein (ADMP) that exerts profound control over the formation of the body axis in development in vertebrates. This protein may provide important regulatory control over nervous system development. The major claims contained in a patent application relating to three other genes (the Cartilage-Derived Morphogenetic Proteins) have been allowed, and seven major biotechnology firms have applied to license them. Two of these proteins are specific to articular cartilage, and during the past year have proven to exert chondrogenic and osteogenic activities. As such, they are leading candidates for clinical applications in bone and joint repair, and for manipulation of autologous cells.Initial studies describing the role of Osteogenic Protein-1 in early vertebrate development were completed and submitted for publication. The salient findings were that this growth factor is a powerful inducer of ventral derivatives; the most striking such effect is a dramatic induction of blood tissue. Another gene, Frzb, originally isolated from mammalian articular cartilage in collaboration with Frank Luyten of NIDR has proven to be a secreted growth factor. Recent experiments in the laboratory have demonstrated that the protein can induce formation of muscle and nerve tissue, and also participates in formation of the body axis in vertebrate organisms. Further, it appears to function as a soluble inhibitor to Wnt growth factors in functional assays. A patent filing on this factor is anticipated shortly.Finally, an improved method for purification of the signal transducing enzyme adenylyl cyclase was published.