MOLECULAR AND CELLULAR MECHANISMS OF HEART DISEASE

心脏病的分子和细胞机制这份修订后的培训补助金续签申请描述了德克萨斯大学休斯顿医学院的心脏病学研究培训计划，该计划将为成功的申请人提供基础分子生物学和生理学研究实验室的研究培训。这些实验室提供心血管医学的研究经验，广泛包括内皮细胞-血细胞相互作用;血管平滑肌增殖对机械和免疫介导的损伤的反应;细胞生长和分化，基于膜功能和细胞内代谢的心肌细胞活力;受体分离，表征，克隆和表达;细胞内信号传导，基因克隆和细胞转染;分子遗传学研究，旨在阐明导致特定心血管疾病的基因;以及基因疗法。健康结果和流行病学研究机会存在于德克萨斯大学休斯顿公共卫生学院的这个项目中。我们相信，一个协调和广泛的培训计划，为学员提供研究培训机会，在生理和临床为导向的研究实验室和基础分子生物学和免疫学实验室，以及在健康成果的研究机会，是在这个程序中可用。参与培训计划的主要教师包括高级NIH资助的基础科学家和临床研究人员。培训计划的主要研究者和主任，培训计划中增加的新教师以及此次竞争性更新的新组织反映了培训计划在心血管分子生物学和健康结局研究方面的扩展和持续努力，期望将基础分子生物学和临床研究整合在一起，以提供心血管科学的全面培训计划。

MOLECULAR AND CELLULAR MECHANISMS OF HEART DISEASE This revised training grant renewal application describes a Cardiology research training program at the University of Texas-Houston Medical School that will provide successful applicants with research training in basic molecular biology and physiologically-oriented research laboratories. These laboratories offer research experience in cardiovascular medicine, broadly including endothelial-blood cell interactions; vascular smooth muscle proliferation in response to mechanical and immunologically-mediated injury; cell growth and differentiation, myocardial cell viability based on membrane function and intracellular metabolism; receptor isolation, characterization, cloning, and expression; intracellular signaling, gene cloning and cell transfection; molecular genetics studies aimed at the elucidation of genes responsible for specific cardiovascular disorders; and gene therapy. Health outcomes and epidemiological research opportunities exist in this program at the University of Texas-Houston School of Public Health. We believe that a coordinated and broad training program that provides trainees with research training opportunities in physiologically and clinically oriented research laboratories and in basic molecular biology and immunology laboratories, as well as in health outcomes research opportunities is available in this program. The principal faculty involved in the training program consists of senior, NIH-funded basic scientists and clinical investigators. The Principal Investigator and Director of the training program, the new faculty added to the training program, and the new organization of this competitive renewal reflect expansion and continued effort of the training program into cardiovascular molecular biology and health outcomes research with the expectation of integrating basic molecular biology and clinically oriented research to provide a comprehensive training program in cardiovascular science.