NEONATAL HOST DEFENSE: BACTERICIDAL & PERMEABILITY INCREASING PROTEIN

新生儿宿主防御：杀菌

• 批准号: 6441969
• 负责人: ERIC EICHENWALD
• 金额: $ 2.88万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6441969
• 关键词: Escherichia coli; adult human (21+); age difference; bacteria infection mechanism; bactericidal immunity; blood proteins; clinical research; host organism interaction; human data; human subject; neutrophil; newborn human (0-6 weeks); protein structure function

The study is aimed at determining whether there are substantive differences in bactericidal/permeability-increasing protein (BPI) content and function between the neutrophils of newborns and adults, by quantitating BPI content immunologically and testing BPI function by antimicrobial effect on E. coli.

本研究采用免疫学方法测定新生儿和成人中性粒细胞杀菌/通透性增加蛋白（BPI）含量，并通过对大肠杆菌的抗菌作用检测BPI功能，以确定新生儿和成人中性粒细胞BPI含量和功能是否存在实质性差异。杆菌