VARIABILITY OF HEART RATE, BLOOD PRESSURE & CEREBRAL OXYGENATION: LBW NEONATES

心率、血压的变化

基本信息

  • 批准号:
    6441968
  • 负责人:
  • 金额:
    $ 2.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-12-01 至 2001-11-30
  • 项目状态:
    已结题

项目摘要

The broad objective of the study is to characterize the physiologic relationships between variability of heart rate, blood pressure, and cerebral oxygenation in a population of preterm newborns at high risk for severe brain injury. The study aims to identify and describe the physiologic antecedents of brain injury in a way that will facilitate subsequent interventional trials. From comparison of repeated measures during the first week of life, the investigators will characterize the developmental maturation of autonomic nervous system modulation of these factors. Previous experiments have found a close correlation between changes in cerebral oxygenation with changes in blood flow velocity as measured by Doppler ultrasound. Data suggests that correlation between fluctuations in mean arterial blood pressure with fluctations in cerebral oxygenation measured by near infrared spectroscopy can stratify likelihood of finding brain injury, including intraventricular hemorrhage and periventricular leukomalacia. An important aim of the study is to confirm and clarify this apparent relation between blood pressure and cerebral oxygenation. Measurement, characterization, and monitoring of unstable cerebral oxygen delivery, and more importantly, its relation to blood pressure and heart rate variability may provide a useful starting point from which to devise neuroprotective clinical strategies. Because blood pressure and heart rate variability are physiologic variables that can be manipulated, the investigators may be able to exploit the relation between these parameters and cerebral oxygenation in a prophylactic manner. Specific Aims: Fourier analysis will be used to quantify variability of cerebral oxygenation. Using coherence functions and transfer functions as previously described, the investigators will evaluate: 1) heart rate variability as a function of blood pressure variability; and 2) variability of cerebral oxygenation as a function of blood pressure variability. The former is a parameter of the baroreflex; the latter of cerebral autoregulation. With respect to transfer functions analysis of the baroreflex and of cerebral autoregulation, blood pressure will be considered the input signal.
这项研究的主要目的是描述重度脑损伤高危早产儿的心率、血压变异性和脑氧合之间的生理关系。这项研究的目的是确定和描述脑损伤的生理学先兆,以便于后续的干预试验。通过比较出生后第一周的重复测量,研究人员将表征自主神经系统发育成熟对这些因素的调节。先前的实验已经发现,大脑氧合的变化与多普勒超声测量的血流速度的变化之间存在密切的相关性。数据表明,通过近红外光谱测量的平均动脉压波动与脑氧合波动之间的相关性可以分层发现脑损伤的可能性,包括脑室出血和脑室周围白质软化症。这项研究的一个重要目的是确认和澄清血压和脑氧合之间的这种明显关系。测量、表征和监测不稳定的脑氧输送,以及更重要的是,它与血压和心率变异性的关系可能为制定神经保护临床策略提供一个有用的起点。由于血压和心率变异性是可以操纵的生理变量,研究人员或许能够以预防性的方式利用这些参数与脑氧合之间的关系。具体目标:傅立叶分析将用于量化脑氧合的变异性。使用如前所述的相干函数和传递函数,研究人员将评估:1)作为血压变异性的函数的心率变异性;以及2)作为血压变异性的函数的脑氧合变异性。前者是压力感受性反射的一个参数,后者是大脑自我调节的一个参数。对于压力感受器反射和脑自动调节的传递函数分析,血压将被认为是输入信号。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ERIC EICHENWALD其他文献

ERIC EICHENWALD的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ERIC EICHENWALD', 18)}}的其他基金

TRIAL OF LATE SURFACTANT TO PREVENT BRONCHOPULMONARY
晚期表面活性剂预防支气管肺损伤的试验
  • 批准号:
    8356693
  • 财政年份:
    2010
  • 资助金额:
    $ 2.88万
  • 项目类别:
FLUCONAZOLE PROPHYLAXIS FOR THE PREVENTION OF CANDIDIASIS IN INFANTS <750 GRAMS
氟康唑预防法预防 <750 克婴儿念珠菌病
  • 批准号:
    8166735
  • 财政年份:
    2009
  • 资助金额:
    $ 2.88万
  • 项目类别:
MULTIPLE DOSE PHARMACOKINETIC STUDY OF MEROPENEM IN YOUNG INFANTS (<91 DAYS)
美罗培南在小婴儿(<91 天)中的多剂量药代动力学研究
  • 批准号:
    8166733
  • 财政年份:
    2009
  • 资助金额:
    $ 2.88万
  • 项目类别:
TRIAL OF LATE SURFACTANT TO PREVENT BRONCHOPULMONARY
晚期表面活性剂预防支气管肺损伤的试验
  • 批准号:
    8166710
  • 财政年份:
    2009
  • 资助金额:
    $ 2.88万
  • 项目类别:
TRIAL OF LATE SURFACTANT TO PREVENT BRONCHOPULMONARY
晚期表面活性剂预防支气管肺损伤的试验
  • 批准号:
    7950663
  • 财政年份:
    2008
  • 资助金额:
    $ 2.88万
  • 项目类别:
LOW DOSE INHALED NITRIC OXIDE FOR TREATMENT AND PREVENTION
低剂量吸入一氧化氮用于治疗和预防
  • 批准号:
    7379223
  • 财政年份:
    2006
  • 资助金额:
    $ 2.88万
  • 项目类别:
LOW DOSE INHALED NITRIC OXIDE FOR TREATMENT AND PREVENTION
低剂量吸入一氧化氮用于治疗和预防
  • 批准号:
    7204486
  • 财政年份:
    2005
  • 资助金额:
    $ 2.88万
  • 项目类别:
Low Dose Inhaled Nitric Oxide for Treatment and Prevention
低剂量吸入一氧化氮用于治疗和预防
  • 批准号:
    7045567
  • 财政年份:
    2003
  • 资助金额:
    $ 2.88万
  • 项目类别:
VARIABILITY OF HEART RATE, BLOOD PRESSURE & CEREBRAL OXYGENATION: LBW NEONATES
心率、血压的变化
  • 批准号:
    6568562
  • 财政年份:
    2001
  • 资助金额:
    $ 2.88万
  • 项目类别:
NEONATAL HOST DEFENSE: BACTERICIDAL & PERMEABILITY INCREASING PROTEIN
新生儿宿主防御:杀菌
  • 批准号:
    6568563
  • 财政年份:
    2001
  • 资助金额:
    $ 2.88万
  • 项目类别:

相似海外基金

A cluster randomized controlled trial to evaluate pharmacy-based health promotion program to improve blood pressure control in Bangladesh, India and Pakistan
一项整群随机对照试验,旨在评估孟加拉国、印度和巴基斯坦基于药房的健康促进计划,以改善血压控制
  • 批准号:
    23K24566
  • 财政年份:
    2024
  • 资助金额:
    $ 2.88万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Defining a new mechanism of blood pressure regulation and its role during sepsis
定义血压调节的新机制及其在脓毒症期间的作用
  • 批准号:
    MR/Y011805/1
  • 财政年份:
    2024
  • 资助金额:
    $ 2.88万
  • 项目类别:
    Research Grant
Blood pressure trajectory of inpatient rehabilitation stroke patients from the Determining Optimal Post-Stroke Exercise (DOSE) trial over the first 12-months post-stroke
通过确定最佳中风后运动 (DOSE) 试验得出的中风住院康复患者在中风后 12 个月内的血压轨迹
  • 批准号:
    493123
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
Cuffless models to infer blood pressure from bioimpedance
无袖带模型可根据生物阻抗推断血压
  • 批准号:
    2319920
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
    Standard Grant
AirPressureNYC: Reducing AIR pollution to lower blood PRESSURE among New York City public housing residents
AirPressureNYC:减少空气污染以降低纽约市公共住房居民的血压
  • 批准号:
    10638946
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
Central Nervous System Reprogramming of the Control of Blood Pressure Induced by Early Life Stress
早期生活压力引起的血压控制的中枢神经系统重新编程
  • 批准号:
    10555126
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
I-Corps: Blood Pressure Monitoring by a Miniaturized Cuffless Sensor
I-Corps:通过小型无袖带传感器进行血压监测
  • 批准号:
    2332674
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
    Standard Grant
Machine Learning Enabled Non-contact Sensing Platform for Blood Pressure and Glucose Prediction
用于血压和血糖预测的机器学习非接触式传感平台
  • 批准号:
    23K11341
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Blood pressure imaging by contrast enhanced active Doppler ultrasound
通过对比增强主动多普勒超声进行血压成像
  • 批准号:
    23K18557
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
The mechanism of non-dipper blood pressure induced by intermittent hypoxia during sleep
睡眠间歇性缺氧引起非杓型血压的机制
  • 批准号:
    23K06336
  • 财政年份:
    2023
  • 资助金额:
    $ 2.88万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了