LOW DOSE INHALED NITRIC OXIDE FOR TREATMENT AND PREVENTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目是一项多中心试验的一部分，其目的是调查低剂量吸入一氧化氮(INO)是否会降低早产儿患慢性肺部疾病的风险。这项干预措施有望将无慢性肺部疾病(月经后36周的氧气依赖)的存活率从50%提高到62%。如果婴儿小于32周，出生体重500至1250克，出生7至21天，并需要机械通气，则符合条件。受试者被随机分配接受iNO(初始剂量为20ppm)或安慰剂。研究用的气体将在三周内断奶。安全性通过监测临床出血和颅内出血、早产儿并发症和两岁时的神经发育结果来评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project, which is part of a multicenter trial, is to investigate whether low dose inhaled nitric oxide (iNO) will decrease the risk of chronic lung disease in premature infants. The intervention is expected to increase survival without chronic lung disease (oxygen dependence at 36 weeks post-menstrual age) from 50 to 62 percent. Infants are eligible if they are less than 32 weeks gestational age, 500 to 1250 g birth weight, 7 to 21 days old, and require mechanical ventilation. Subjects are randomly assigned to receive iNO (initial dose 20 ppm) or placebo. The study gas is weaned over a three week period. Safety is evaluated by monitoring clinical bleeding and intracranial hemorrhage, complications of prematurity, and neurodevelopmental outcome at two years of age.