LOW DOSE INHALED NITRIC OXIDE FOR TREATMENT AND PREVENTION

低剂量吸入一氧化氮用于治疗和预防

• 批准号: 7379223
• 负责人: ERIC EICHENWALD
• 金额: $ 0.92万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379223
• 关键词: LOW; DOSE; INHALED; NITRIC; OXIDE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project, which is part of a multicenter trial, is to investigate whether low dose inhaled nitric oxide (iNO) will decrease the risk of chronic lung disease in premature infants. The intervention is expected to increase survival without chronic lung disease (oxygen dependence at 36 weeks post-menstrual age) from 50 to 62 percent. Infants are eligible if they are less than 32 weeks gestational age, 500 to 1250 g birth weight, 7 to 21 days old, and require mechanical ventilation. Subjects are randomly assigned to receive iNO (initial dose 20 ppm) or placebo. The study gas is weaned over a three week period. Safety is evaluated by monitoring clinical bleeding and intracranial hemorrhage, complications of prematurity, and neurodevelopmental outcome at two years of age.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目是一项多中心试验的一部分，其目的是调查低剂量吸入一氧化氮（iNO）是否会降低早产儿慢性肺部疾病的风险。该干预措施预计将无慢性肺部疾病（月经后36周的氧依赖性）的生存率从50%提高到62%。如果婴儿胎龄小于32周，出生体重500 - 1250 g，出生7 - 21天，需要机械通气，则符合条件。受试者被随机分配接受iNO（初始剂量20 ppm）或安慰剂。研究气体在三周内断奶。通过监测临床出血和颅内出血、早产儿并发症和两岁时的神经发育结果来评价安全性。