CORE--BIOSTATISTICS

综合口腔健康发现研究中心（COHRCD）涉及的项目包括临床前研究、转化研究、临床和行为干预试验、有效性研究和卫生服务研究。生物统计和研究设计（BARD）核心将为每项研究量身定制支持，因为每个项目都有特定的研究设计和统计分析需求。BARD核心将为所有COHRCD项目和调查人员提供建议、教育和统计咨询。BARD核心将继续与研究人员合作，完善方案和数据收集工具，将最终确定随机化时间表、数据管理、监测、质量控制和可靠性的计划；协调整合来自不同项目的数据库，以实现更强大、独特的多元分析；为基线、中期和最终分析提供统计咨询；教育研究人员如何为他们的研究设计和分析选择统计方法，以及如何解释结果；促进在加州大学旧金山分校牙科学院诊所建立一个更全面的电子病历数据库；通过“无墙临床研究中心”，推动以试点项目、重大研究中间成果、住院医师、研究生、博士后、教师等为基础开展高质量研究。与研究过程中的任何其他步骤一样，应给予研究的数据分析方面足够的时间和精力。巴德的博士级核心人员有超过70人年的合作研究经验，可以充分满足这些需求。

The Comprehensive Oral Health Research Center of Discovery (COHRCD) involves projects ranging from pre-clinical studies to translational studies, clinical and behavioral intervention trials, effectiveness research, and health services research. The Biostatistical and Research Design (BARD) Core will tailor support for each study, since each project has specific research design and statistical analysis needs. The BARD Core will provide advice, education, and statistical consulting to all COHRCD projects and investigators. The BARD Core will continue to work with investigators to refine protocols and data collection instruments, will finalize plans for randomization schedules, data management, monitoring, quality control and reliability; coordinate integrating databases from different projects to enable more powerful, unique multivariate analyses; provide statistical consulting for baseline, interim, and final analyses; educate researchers about selecting statistical methods for their research design and analyses and about interpreting the results; foster developing a more comprehensive electronic patient record database in the UCSF School of Dentistry clinics; and promote the development of quality research studies based on pilot projects, on intermediate results on major studies, and on related endeavors from residents, graduate students, postdoctoral fellows, and faculty via the Clinical Research Center without Walls. Sufficient time and effort should be given to the data analytic aspects of research, as with any other step in the research process. The doctoral level BARD Core personnel have over 70 person-years of collaborative research experience and can adequately fulfill those needs.