Microscopic diffusion anisotropy imaging

显微扩散各向异性成像

• 批准号: 1902617
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1902617
• 关键词: Microscopic; diffusion; anisotropy; imaging

The microstructure of brain tissue is critical to neural function and health. Magnetic resonance imaging (MRI) is a non-invasive technique for the assessment of microstructural features and therefore offers untapped potential to study both brain development and neurodevelopmental disorders in preclinical setting and living humans. The aim of this project is to pioneer advanced MRI techniques enabling to monitor the microscopic progression of nervous tissue structure in vivo. Specifically, we will exploit the diffusion process of water molecules as a fingerprint to recover tissue microstructure using the latest MRI technology, computational modelling and machine-learning methods.

脑组织的微结构对神经功能和健康至关重要。磁共振成像(MRI)是一种评估微结构特征的非侵入性技术，因此为研究临床前环境和活体人类的脑发育和神经发育障碍提供了尚未开发的潜力。该项目的目的是开创先进的核磁共振技术，使其能够监测体内神经组织结构的微观进展。具体地说，我们将利用水分子的扩散过程作为指纹，利用最新的磁共振技术、计算模型和机器学习方法恢复组织的微观结构。

项目成果

On the potential for mapping apparent neural soma density via a clinically viable diffusion MRI protocol.

• DOI: 10.1016/j.neuroimage.2021.118303
• 发表时间: 2021-10-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Gyori NG;Clark CA;Alexander DC;Kaden E
• 通讯作者: Kaden E