Harnessing ancient DNA information content to infer evolutionary histories

利用古代 DNA 信息内容来推断进化历史

• 批准号: 1902705
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1902705
• 关键词: Harnessing; ancient; DNA; information; content

DNA from ancient remains (aDNA) provides a direct window into our past and has revolutionized our understanding of migratory patterns in humans (ref 1) and other animals (2,3). However, major challenges such as poor data quality still prevent us from fully exploiting the enormous potential of aDNA. In particular, current methods ignore correlations among neighboring genetic markers, even though this would substantially increase our power to infer demographic histories. This project will develop and apply novel statistical methods for low-quality aDNA, in order to extract previously unobtainable, yet crucial, information about the evolutionary histories of humans and their domestic animals.

来自古代遗骸的DNA(ADNA)提供了了解我们过去的直接窗口，并彻底改变了我们对人类和其他动物迁徙模式的理解(参考文献1)和其他动物(文献2，3)。然而，数据质量差等重大挑战仍然阻碍着我们充分利用aDNA的巨大潜力。特别是，目前的方法忽略了相邻遗传标记之间的相关性，尽管这将大大增加我们推断人口历史的能力。该项目将开发和应用低质量aDNA的新统计方法，以提取以前无法获得的、但至关重要的关于人类及其家养动物进化史的信息。