Harnessing ancient DNA information content to infer evolutionary histories

来自古代遗骸的DNA（aDNA）为我们的过去提供了一个直接的窗口，并彻底改变了我们对人类（参考文献1）和其他动物（2，3）迁移模式的理解。然而，数据质量差等重大挑战仍然阻碍我们充分利用aDNA的巨大潜力。特别是，目前的方法忽略了相邻遗传标记之间的相关性，即使这将大大增加我们推断人口统计学历史的能力。该项目将为低质量的aDNA开发和应用新的统计方法，以提取以前无法获得的，但至关重要的关于人类及其家畜进化历史的信息。

DNA from ancient remains (aDNA) provides a direct window into our past and has revolutionized our understanding of migratory patterns in humans (ref 1) and other animals (2,3). However, major challenges such as poor data quality still prevent us from fully exploiting the enormous potential of aDNA. In particular, current methods ignore correlations among neighboring genetic markers, even though this would substantially increase our power to infer demographic histories. This project will develop and apply novel statistical methods for low-quality aDNA, in order to extract previously unobtainable, yet crucial, information about the evolutionary histories of humans and their domestic animals.