CENTER FOR STRUCTURAL BIOLOGY

该提案描述了三项相互关联的核心活动(蛋白质组学、生物信息学、外联)，旨在建立一个多学科研究团队，以应对基因组学下一个更具挑战性的阶段，即基因产品如何产生功能。在指导委员会和咨询委员会的指导下，在行政核心的协助下，布林结构生物学中心将通过与该领域的顶级专家进行互访和咨询，提供高通量蛋白质组学技术。蛋白质结构是功能的核心，围绕这一主题，我们Brin提案的巩固目标将是培育、培训和提供网络资源，从而带来来自新罕布夏州的最佳研究和更具竞争力的研究应用。为了应对这些挑战，我们描述了：(I)一个由成熟的和年轻的研究人员提交的蛋白质组学问题联盟，以建立指导关系；(Ii)将新的重点放在生物信息学的下一阶段，将数据质量从数量中分离出来；(Iii)一个集中的研究中心，用于服务和发展；以及(Iv)针对较小的大学和高中(及其学生)的教师培训外展计划，其支线概念是鼓励最优秀和最聪明的人从事与健康相关的研究。在这一综合方法中，该计划的具体目标是首先将蛋白质组学、生物信息学和核心资源的最佳技术与新的设施、仪器和终身教职聘用相匹配。其次，我们选择了问题(蛋白质相互作用、图谱、糖组学、传感器芯片)和合作者(维达尔、沙克特、丹尼斯、塞茨)，介绍了接近基因组功能的下一个维度的策略，表征了蛋白质的时空表达模式，以及它们潜在的相互作用伙伴。这些将是功能注释的主干，可以根据这些注释来制定新的生物学问题。最后，为了确保这些人员和物质资源为成长和自给自足埋下种子，我们为今天的教师和明天的学生引入了一个广泛的网络计划。暑期仪器和生物信息学培训方案以及演讲者论坛之后，将有选择地向联网学校分发仪器。这些地方文书不仅将作为本土研究和教学的工具，而且还将通过全州范围的网络促进进一步的生物学探索和研究。通过研究生科学教学(霍普金斯，鲍尔，分别)，在K-12的有经验的人的指导和指导下，我们计划的这一部分可能是最令人信服和持久的。

This proposal describes three interrelated Core activities (Proteomics, Bioinformatics, Outreach) that have been cast bo build a multi- disciplinary research team to address the next, more challenging phase of genomics, how gene products give rise to function. Guided by Steering and Advisory committees, with routine operations assisted by an Administrative Core, this BRIN Center for Structural Biology will provide access to high-throughput proteomics technology, molded by exchanged visits and consultation with top experts in the field. Protein structure is central to function, and around this theme the consolidating aim of our BRIN proposal will be to nurture, train, and provide a networking resource that will bring forth the best research and more competitive research applications from the State of New Hampshire. To meet these challenges we describe: (i) a consortium of proteomics problems submitted by established and young investigators to build mentoring relationships; (ii) a new focus on the next-phase of bioinformatics to disentangle data quality from quantity; (iii) a centralized research center for service, and development; and, (iv) an outreach program of teacher training for smaller college and high schools, (and their students), with a feeder concept to encourage the best and brightest to pursue careers in health-related research. In this comprehensive approach, it is the specific goal of this Program to first match the best technology in proteomics, bioinformatics, and core resources with new facilities, instrumentation, and tenure-track hires. Second, we have selected problems (protein interaction, mapping, glycomics, sensor chips) and collaborators, (Vidal, Schachter, Dennis, Seitz), that introduce strategies to approach the next dimension of genome function, characterizing protein spatial and temporal expression patterns, and their potential interacting partners. These will be the backbone of functional annotations from which new biological questions can be formulated. Finally, to insure that these personnel and physical resources lay the seeds for growth and self-sufficiency, we introduce an extensive networking program for today's teachers, and tomorrow's students. Summer instrumental and bioinformatics training programs, and speaker forums will be followed by selective distribution of instruments to networking schools. These local instruments will not only serve as tools for indigenous research and teaching, but catalyze further biological inquiry and research through the State-wide network. Directed and guided by experienced hands in K-12 through graduate science teaching (Hopkins, Bauer, resp.,), this component of our Program may be the most compelling and long lasting.