CENTER FOR STRUCTURAL BIOLOGY

该提案描述了三个相互关联的核心活动（蛋白质组学、生物信息学、外展），旨在建立一个多学科研究团队，以解决基因组学下一个更具挑战性的阶段，即基因产物如何产生功能。 BRIN 结构生物学中心在指导委员会和咨询委员会的指导下，在行政核心的协助下进行日常运营，将提供高通量蛋白质组学技术，该技术是通过与该领域顶级专家的互访和咨询而形成的。蛋白质结构是功能的核心，围绕这一主题，我们 BRIN 提案的综合目标将是培育、培训和提供网络资源，从而带来新罕布什尔州最好的研究和更具竞争力的研究应用。为了应对这些挑战，我们描述了：（i）由成熟的和年轻的研究人员提交的蛋白质组学问题联盟，以建立指导关系； (ii) 新的重点关注生物信息学的下一阶段，以将数据质量与数量分开； (iii) 服务和开发集中研究中心； (iv) 针对规模较小的大学和高中（及其学生）的教师培训外展计划，以支线概念鼓励最优秀和最聪明的人从事健康相关研究的职业。在这种综合方法中，该计划的具体目标是首先将蛋白质组学、生物信息学和核心资源方面的最佳技术与新设施、仪器和终身职位聘用相匹配。其次，我们选择了问题（蛋白质相互作用、图谱、糖组学、传感器芯片）和合作者（Vidal、Schachter、Dennis、Seitz），它们引入了接近基因组功能的下一个维度的策略，表征蛋白质空间和时间表达模式及其潜在的相互作用伙伴。这些将成为功能注释的支柱，可以从中提出新的生物学问题。最后，为了确保这些人员和物质资源为成长和自给自足奠定基础，我们为今天的教师和明天的学生引入了广泛的网络计划。夏季仪器和生物信息学培训计划以及演讲者论坛之后将有选择地向网络学校分发仪器。这些地方文书不仅将作为本土研究和教学的工具，还将通过全州网络促进进一步的生物学探究和研究。我们计划的这一部分由经验丰富的 K-12 研究生科学教学人员（霍普金斯、鲍尔等）指导和指导，可能是最引人注目和最持久的。

This proposal describes three interrelated Core activities (Proteomics, Bioinformatics, Outreach) that have been cast bo build a multi- disciplinary research team to address the next, more challenging phase of genomics, how gene products give rise to function. Guided by Steering and Advisory committees, with routine operations assisted by an Administrative Core, this BRIN Center for Structural Biology will provide access to high-throughput proteomics technology, molded by exchanged visits and consultation with top experts in the field. Protein structure is central to function, and around this theme the consolidating aim of our BRIN proposal will be to nurture, train, and provide a networking resource that will bring forth the best research and more competitive research applications from the State of New Hampshire. To meet these challenges we describe: (i) a consortium of proteomics problems submitted by established and young investigators to build mentoring relationships; (ii) a new focus on the next-phase of bioinformatics to disentangle data quality from quantity; (iii) a centralized research center for service, and development; and, (iv) an outreach program of teacher training for smaller college and high schools, (and their students), with a feeder concept to encourage the best and brightest to pursue careers in health-related research. In this comprehensive approach, it is the specific goal of this Program to first match the best technology in proteomics, bioinformatics, and core resources with new facilities, instrumentation, and tenure-track hires. Second, we have selected problems (protein interaction, mapping, glycomics, sensor chips) and collaborators, (Vidal, Schachter, Dennis, Seitz), that introduce strategies to approach the next dimension of genome function, characterizing protein spatial and temporal expression patterns, and their potential interacting partners. These will be the backbone of functional annotations from which new biological questions can be formulated. Finally, to insure that these personnel and physical resources lay the seeds for growth and self-sufficiency, we introduce an extensive networking program for today's teachers, and tomorrow's students. Summer instrumental and bioinformatics training programs, and speaker forums will be followed by selective distribution of instruments to networking schools. These local instruments will not only serve as tools for indigenous research and teaching, but catalyze further biological inquiry and research through the State-wide network. Directed and guided by experienced hands in K-12 through graduate science teaching (Hopkins, Bauer, resp.,), this component of our Program may be the most compelling and long lasting.