CENTER FOR STRUCTURAL BIOLOGY

该提案描述了三个相互关联的核心活动（蛋白质组学，生物信息学，外展），这些活动已被铸造以建立一个多学科的研究团队，以解决基因组学的下一个更具挑战性的阶段，基因产物如何产生功能。在指导和咨询委员会的指导下，在行政核心的协助下进行常规操作，BRIN结构生物学中心将提供高通量蛋白质组学技术，通过与该领域顶级专家的互访和咨询来塑造。蛋白质结构是核心功能，围绕这一主题，我们BRIN提案的巩固目标将是培育，培训和提供一个网络资源，将带来最好的研究和更具竞争力的研究应用程序从新罕布什尔州。为了迎接这些挑战，我们描述：（i）一个联盟的蛋白质组学问题提交的建立和年轻的研究人员建立指导关系;（ii）一个新的重点下一阶段的生物信息学解开数据质量从数量;（iii）一个集中的研究中心的服务和发展;以及（四）为规模较小的大学和高中（及其学生）提供教师培训的推广方案，其概念是鼓励最优秀和最聪明的人从事与健康有关的研究。在这种全面的方法中，该计划的具体目标是首先将蛋白质组学，生物信息学和核心资源中的最佳技术与新设施，仪器和终身教职人员相匹配。其次，我们选择了问题（蛋白质相互作用，映射，糖组学，传感器芯片）和合作者（Vidal，Schachter，Dennis，Seitz），引入策略来接近基因组功能的下一个维度，表征蛋白质的空间和时间表达模式，以及它们潜在的相互作用伙伴。这些将是功能注释的基础，新的生物学问题可以从这些注释中制定出来。最后，为了确保这些人员和物质资源为成长和自给自足奠定基础，我们为今天的教师和明天的学生引入了一个广泛的网络计划。夏季仪器和生物信息学培训计划，和扬声器论坛之后，将有选择地分配仪器网络学校。这些地方文书不仅将作为土著研究和教学的工具，而且将通过全州网络促进进一步的生物调查和研究。指导和指导经验丰富的手在K-12通过研究生科学教学（霍普金斯，鲍尔，分别，），我们计划的这一部分可能是最引人注目和持久的。

This proposal describes three interrelated Core activities (Proteomics, Bioinformatics, Outreach) that have been cast bo build a multi- disciplinary research team to address the next, more challenging phase of genomics, how gene products give rise to function. Guided by Steering and Advisory committees, with routine operations assisted by an Administrative Core, this BRIN Center for Structural Biology will provide access to high-throughput proteomics technology, molded by exchanged visits and consultation with top experts in the field. Protein structure is central to function, and around this theme the consolidating aim of our BRIN proposal will be to nurture, train, and provide a networking resource that will bring forth the best research and more competitive research applications from the State of New Hampshire. To meet these challenges we describe: (i) a consortium of proteomics problems submitted by established and young investigators to build mentoring relationships; (ii) a new focus on the next-phase of bioinformatics to disentangle data quality from quantity; (iii) a centralized research center for service, and development; and, (iv) an outreach program of teacher training for smaller college and high schools, (and their students), with a feeder concept to encourage the best and brightest to pursue careers in health-related research. In this comprehensive approach, it is the specific goal of this Program to first match the best technology in proteomics, bioinformatics, and core resources with new facilities, instrumentation, and tenure-track hires. Second, we have selected problems (protein interaction, mapping, glycomics, sensor chips) and collaborators, (Vidal, Schachter, Dennis, Seitz), that introduce strategies to approach the next dimension of genome function, characterizing protein spatial and temporal expression patterns, and their potential interacting partners. These will be the backbone of functional annotations from which new biological questions can be formulated. Finally, to insure that these personnel and physical resources lay the seeds for growth and self-sufficiency, we introduce an extensive networking program for today's teachers, and tomorrow's students. Summer instrumental and bioinformatics training programs, and speaker forums will be followed by selective distribution of instruments to networking schools. These local instruments will not only serve as tools for indigenous research and teaching, but catalyze further biological inquiry and research through the State-wide network. Directed and guided by experienced hands in K-12 through graduate science teaching (Hopkins, Bauer, resp.,), this component of our Program may be the most compelling and long lasting.