INDUCTION AND PATTERNING OF NEURAL TUBE VENTRAL MIDLINE

神经管腹侧中线的感应和图案化

基本信息

  • 批准号:
    6410641
  • 负责人:
  • 金额:
    $ 25.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-12-01 至 2001-11-30
  • 项目状态:
    已结题

项目摘要

The overall goal of this work is to understand the molecular and cellular basis for the acquisition of distinct cell fates along the rostrocaudal axis of the developing neural tube. The focus of the work is the differentiation of the ventral midline cell group which, in caudal regions, comprises the floor plate and, more rostrally, spans the ventral midline of the rostral forebrain. These cells play major roles in the patterning of cells and axons within the dorsoventral axis of the neural tube but the properties of the ventral cell groups differ at different rostrocaudal positions along the axis. In caudal regions, the floor plate is induce by signals from the underlying axial mesoderm cells of the notochord. In rostral diencephalon, the induction of the midline cells appears to be controlled by different axial mesoderm, the prechordal mesoderm. Furthermore, although the signalling molecule, Sonic Hedgehog, mediates the induction and differentiation of the floor plate, in the rostral forebrain a second signalling factor, BMP7, is required to act in concert with Sonic Hedgehog, apparently sensitizing neural cells to Sonic Hedgehog signalling, to induce cells with rostral character. The aims of this proposal are to examine in detail the role of BMP7 in rostralization of the ventral midline and to determine the mechanisms underlying this novel interaction between BMP7 and Sonic Hedgehog. The main experimental tool will be in vitro explant assays, which permit the response of neural plate tissue to signals from mesoderm to be monitored and manipulated. These will be used in conjunction with mice in which genes encoding components of the proposed pathways of differentiation have been functionally inactivated. Experiments will trace the site of action of BMP7 and will investigate potential mechanisms of its action on neural tissue. In addition, we will determine whether related transcription factors mediate the initial events in response to Sonic Hedgehog in distinct populations of midline cells. The possibility that additional agents are involved in the rostrocaudal patterning of ventral midline regions intermediate between rostral forebrain and caudal floor plate will also be examined. The distribution and role of BMP function-blocking proteins will be studied. Together, these experiments will lead to an understanding of the mechanisms underling the differential patterning and properties of the floor plate and ventral midline cells of the rostral forebrain. In addition, however, they will provide insight more generally into rostrocaudal patterning of neural tissue, revealing mechanisms and candidate molecules that are involved in defining this axis of the neural plate.
这项工作的总体目标是了解分子和细胞

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JANE DODD其他文献

JANE DODD的其他文献

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{{ truncateString('JANE DODD', 18)}}的其他基金

Linking the molecular logic of sensory neuron diversity and somatosensory circuitry in mouse spinal cord: development of novel tools for viral tracing and 3D analysis
将小鼠脊髓感觉神经元多样性的分子逻辑与体感回路联系起来:开发病毒追踪和 3D 分析的新工具
  • 批准号:
    10307604
  • 财政年份:
    2020
  • 资助金额:
    $ 25.59万
  • 项目类别:
Linking the molecular logic of sensory neuron diversity and somatosensory circuitry in mouse spinal cord: development of novel tools for viral tracing and 3D analysis
将小鼠脊髓感觉神经元多样性的分子逻辑与体感回路联系起来:开发病毒追踪和 3D 分析的新工具
  • 批准号:
    10156647
  • 财政年份:
    2020
  • 资助金额:
    $ 25.59万
  • 项目类别:
Trans-Synaptic Tracing of Developing Somatosensory Circuits
发育中的体感回路的跨突触追踪
  • 批准号:
    9066828
  • 财政年份:
    2015
  • 资助金额:
    $ 25.59万
  • 项目类别:
INDUCTION AND PATTERNING OF NEURAL TUBE VENTRAL MIDLINE
神经管腹侧中线的感应和图案化
  • 批准号:
    6565238
  • 财政年份:
    2001
  • 资助金额:
    $ 25.59万
  • 项目类别:
INDUCTION AND PATTERNING OF NEURAL TUBE VENTRAL MIDLINE
神经管腹侧中线的感应和图案化
  • 批准号:
    6302809
  • 财政年份:
    1999
  • 资助金额:
    $ 25.59万
  • 项目类别:
INDUCTION AND PATTERNING OF NEURAL TUBE VENTRAL MIDLINE
神经管腹侧中线的感应和图案化
  • 批准号:
    6112406
  • 财政年份:
    1998
  • 资助金额:
    $ 25.59万
  • 项目类别:
INDUCTION AND PATTERNING OF NEURAL TUBE VENTRAL MIDLINE
神经管腹侧中线的感应和图案化
  • 批准号:
    6296945
  • 财政年份:
    1998
  • 资助金额:
    $ 25.59万
  • 项目类别:
INDUCTION AND PATTERNING OF NEURAL TUBE VENTRAL MIDLINE
神经管腹侧中线的感应和图案化
  • 批准号:
    6273803
  • 财政年份:
    1998
  • 资助金额:
    $ 25.59万
  • 项目类别:
CONTROL OF FLOOR PLATE INDUCTION BY AXIAL MESODERM
轴向中胚层对底板感应的控制
  • 批准号:
    6243711
  • 财政年份:
    1996
  • 资助金额:
    $ 25.59万
  • 项目类别:
CORE--ANTIBODY
核心--抗体
  • 批准号:
    6243716
  • 财政年份:
    1996
  • 资助金额:
    $ 25.59万
  • 项目类别:
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