Dopaminergic modulation of belief-relevant cognitive processing: implications for the psychosis-spectrum

信念相关认知处理的多巴胺能调节：对精神病谱系的影响

• 批准号: 1917183
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1917183
• 关键词: Dopaminergic; modulation; belief; relevant; cognitive

Alterations to the mesolimbic dopamine system, particularly increased pre-synaptic dopamine synthesis, have been consistently associated with psychosis and several models associate this system with delusions and hallucinations through aberrant salience, reward prediction or associative learning. However, as delusions are considered pathologies of belief, this would also suggest that this system has a role in components of normal belief formation. Through the use of pharmacological modulation, this project aims to understand the effect of alteration to the mesolimbic dopaminergic pathway on belief-related cognitive processes in the non-clinical and subclinical range to help understand the role of dopamine in the full spectrum of belief - linking the continuum of typical and pathological belief. We will test the hypothesis that i) dopamine modulation is associated with greater changes in beliefs more closely related to the psychosis spectrum, and the perceived self-relevance of beliefs in general; (ii) that these effects will be modulated by baseline schizotypy measures - indicating a role for the dopamine system in susceptibility to atypical beliefs outside the clinical spectrum.

中脑边缘多巴胺系统的改变，特别是突触前多巴胺合成的增加，一直与精神病相关，并且一些模型通过异常显着性、奖励预测或联想学习将该系统与妄想和幻觉联系起来。然而，由于妄想被认为是信仰的病态，这也表明该系统在正常信仰形成的组成部分中发挥着作用。通过使用药理调节，该项目旨在了解中脑边缘多巴胺能通路的改变对非临床和亚临床范围内的信念相关认知过程的影响，以帮助了解多巴胺在整个信念谱中的作用 - 连接典型信念和病理信念的连续体。我们将检验以下假设：i）多巴胺调节与与精神病谱系更密切相关的信念的更大变化以及一般信念的感知自我相关性相关； （ii）这些效应将通过基线精神分裂测量来调节——表明多巴胺系统在对临床谱系之外的非典型信念的易感性中发挥着作用。

项目成果

Paranoia, sensitisation and social inference: findings from two large-scale, multi-round behavioural experiments.

偏执、敏感化和社会推理：两项大规模、多轮行为实验的发现。

• DOI: 10.31234/osf.io/2j7ms
• 发表时间: 2019
• 作者: Barnby J