Exogenous Modulation of Visual Perception And Connectivity in Body Dysmorphic Disorder (EMPAC-BDD)

身体变形障碍中视觉感知和连接的外源调节(EMPAC-BDD)

基本信息

  • 批准号:
    10355356
  • 负责人:
  • 金额:
    $ 13.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Individuals with body dysmorphic disorder (BDD) misperceive aspects of their appearance to be conspicuously flawed or defective, despite these being unnoticeable or appearing miniscule to others. With convictions of disfigurement and ugliness, they typically have poor insight or delusional beliefs, obsessive thoughts and compulsive behaviors, anxiety, and depression. These result in significant difficulties in functioning, depression, suicide attempts (25%), and psychiatric hospitalization (50%). Despite this, relatively few studies of the neurobiology, and few treatment studies, have been conducted. This underscores a critical need for research to identify novel targets for intervention based on a comprehensive understanding of the pathophysiological mechanisms. Previous research has uncovered mechanisms that may contribute to perceptual distortions, including prominent abnormalities in visual processing systems. These have contributed to a model of diminished global/holistic processing and enhanced local/detailed processing, attributed to “bottom-up” and “top-down” disturbances in perception. Previous experiments using psychophysical tests, novel behavioral visual modulation techniques, and functional magnetic resonance imaging (fMRI) have probed the brain’s visual systems responsible for global and local processing and found early evidence that they may be modifiable in BDD. This study will test if further modification could be achieved using noninvasive neuromodulation with repetitive transcranial magnetic stimulation (TMS). Such modulation may be necessary to enhance the effects of behavioral modulation and induce the magnitude of functional changes necessary to achieve clinically meaningful improvements in perceptual experiences in those with BDD. The proposed experiment will determine whether excitatory and inhibitory TMS enhances and inhibits, respectively, the effects of a behavioral visual modulation strategy on brain connectivity and on global visual processing on a psychophysical task. This will be tested in individuals with clinical BDD and in individuals with subclinical BDD. Results will contribute to a comprehensive mechanistic model of abnormal visual information processing underlying the core symptom domain of misperceptions of appearance. Further, results will be critical for the development and optimization of future combinations of neuromodulation and novel perceptual retraining treatments.
项目摘要 患有身体畸形恐惧症(BDD)的人错误地认为他们的外表是明显的, 有瑕疵或缺陷的,尽管这些在别人看来是不明显的或微不足道的。被判有罪 他们通常有不良的洞察力或妄想的信念,强迫性的想法, 强迫行为焦虑和抑郁这导致运作上的重大困难, 抑郁症、自杀企图(25%)和精神病住院(50%)。尽管如此,相对较少的研究 进行了神经生物学和少数治疗研究。这突出表明,迫切需要 研究,以确定新的干预目标的基础上,全面了解 病理生理机制以前的研究已经揭示了可能有助于 知觉失真,包括视觉处理系统的显著异常。这些都有助于 一种减少整体/整体处理和增强局部/细节处理的模型,归因于 “自下而上”和“自上而下”的干扰。以前的实验使用心理物理测试, 新的行为视觉调节技术和功能性磁共振成像(fMRI)已经 探索负责全局和局部处理的大脑视觉系统,并发现了早期证据, 它们可以在BDD中修改。这项研究将测试是否可以实现进一步的修改, 重复经颅磁刺激(TMS)的神经调节。这种调制可能是必要的 增强行为调节的效果,并诱导必要的功能变化的幅度, 在BDD患者的感知体验中实现临床上有意义的改善。拟议 实验将确定兴奋性和抑制性TMS是否分别增强和抑制, 行为视觉调节策略对大脑连接和整体视觉处理的影响 心理物理任务这将在临床BDD个体和亚临床BDD个体中进行测试。 研究结果将有助于建立一个全面的异常视觉信息加工机制模型 这是对外表误解的核心症状领域的基础。此外,结果对于 神经调节和新感知再训练的未来组合的开发和优化 治疗。

项目成果

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Jamie Feusner其他文献

Jamie Feusner的其他文献

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{{ truncateString('Jamie Feusner', 18)}}的其他基金

Exogenous Modulation of Visual Perception And Connectivity in Body Dysmorphic Disorder (EMPAC-BDD)
身体变形障碍中视觉感知和连接的外源调节(EMPAC-BDD)
  • 批准号:
    10655303
  • 财政年份:
    2022
  • 资助金额:
    $ 13.64万
  • 项目类别:
Personalized 3D avatar tool development for measurement of body perception across gender identities
个性化 3D 头像工具开发,用于测量跨性别身份的身体感知
  • 批准号:
    10372079
  • 财政年份:
    2021
  • 资助金额:
    $ 13.64万
  • 项目类别:
Neural mechanisms of perceptual abnormalities and their malleability in body dysmorphic disorder
身体变形障碍知觉异常的神经机制及其可塑性
  • 批准号:
    10457082
  • 财政年份:
    2020
  • 资助金额:
    $ 13.64万
  • 项目类别:
Neural mechanisms of perceptual abnormalities and their malleability in body dysmorphic disorder
身体变形障碍知觉异常的神经机制及其可塑性
  • 批准号:
    10641908
  • 财政年份:
    2020
  • 资助金额:
    $ 13.64万
  • 项目类别:
Understanding the dynamics of visual processing abnormalities in body dysmorphic disorder
了解身体变形障碍视觉处理异常的动态
  • 批准号:
    9313611
  • 财政年份:
    2017
  • 资助金额:
    $ 13.64万
  • 项目类别:
Gender identity and own body perception implications for the neurobiology of gender dysphoria
性别认同和自己的身体感知对性别不安的神经生物学的影响
  • 批准号:
    10006729
  • 财政年份:
    2017
  • 资助金额:
    $ 13.64万
  • 项目类别:
Anxiety and reward interaction and prediction of outcomes in anorexia nervosa
焦虑和奖赏相互作用以及神经性厌食症结果的预测
  • 批准号:
    9248096
  • 财政年份:
    2015
  • 资助金额:
    $ 13.64万
  • 项目类别:
Anxiety and reward interaction and prediction of outcomes in anorexia nervosa
焦虑和奖赏相互作用以及神经性厌食症结果的预测
  • 批准号:
    9237319
  • 财政年份:
    2015
  • 资助金额:
    $ 13.64万
  • 项目类别:
Anxiety and reward interaction and prediction of outcomes in anorexia nervosa
焦虑和奖赏相互作用以及神经性厌食症结果的预测
  • 批准号:
    8965487
  • 财政年份:
    2015
  • 资助金额:
    $ 13.64万
  • 项目类别:
Common and Distinct Phenotypes of Body Dysmorphic Disorder and Anorexia Nervosa
身体畸形障碍和神经性厌食症的常见和独特表型
  • 批准号:
    8087974
  • 财政年份:
    2011
  • 资助金额:
    $ 13.64万
  • 项目类别:

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