MECHANISMS OF ADENOVIRUS VACCINES FOR COLON CANCER

腺病毒疫苗治疗结肠癌的机制

基本信息

  • 批准号:
    6410215
  • 负责人:
  • 金额:
    $ 22.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-01-12 至 2001-12-31
  • 项目状态:
    已结题

项目摘要

The major goal of this project is to identify an optimal adenovirus- based vaccination strategy against homologue (mEGP) of the human colorectal carcinoma-associated GA733 antigen. Since mice express mEGP on normal tissues (similar to GA733 Ag in humans), this animal model allows testing of the vaccine in an immunologically tolerant host and evaluation of potential toxicity. These studies will optimize the ability of this vaccine to overcome tolerance to this tumor antigen in settings that closely mimic patients with colon cancer. Therefore, they will have an impact on the initial human clinical trial (see Project 3, Aim 2) and will provide the basis for the testing of improved human colon cancer vaccines in the near future. We have prepared an adenovirus-based mEGP vaccine and have already shown that it can induce tumor protection in the mouse when used in combination with interleukin-2 (IL-2). This is the basis for our proposed series of experiments. Our initial experiments will address issues of immediate clinical relevance, i.e., administration of the vaccine by a cutaneous route, the need for one versus two doses of the vaccine, and the appropriate use of cytokine. Having identified parameters that limit or enhance our vaccine in a subcutaneous tumor model, we will than address whether our vaccination strategy is effective against more advanced and metastatic disease. This will provide us with the opportunity to improve our vaccine by studying the effects of different booster strategies, the use of other cytokines and the use of functionally active fragments (from Project 1) of mEGP. Having optimized our vaccine, we will study its mechanism of action by defining the target cells through which the adenovirus elicits anti-mEGP immunity, the role of the adenoviral proteins in the induction of the immune response, and the cell types that contribute to the effectiveness of the immune response.
本课题的主要目标是确定一种最佳的腺病毒

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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STEPHEN L. ECK其他文献

STEPHEN L. ECK的其他文献

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{{ truncateString('STEPHEN L. ECK', 18)}}的其他基金

MECHANISMS OF ADENOVIRUS VACCINES FOR COLON CANCER
腺病毒疫苗治疗结肠癌的机制
  • 批准号:
    6563875
  • 财政年份:
    2002
  • 资助金额:
    $ 22.84万
  • 项目类别:
INHIBITION OF T CELLS BY A TUMOR ASSOCIATED PROTEIN
肿瘤相关蛋白对 T 细胞的抑制
  • 批准号:
    6258523
  • 财政年份:
    2001
  • 资助金额:
    $ 22.84万
  • 项目类别:
TREATMENT OF RECURRENT/PROGRESSIVE MALIGNANT GLIOMA WITH H5 010CMVHINF ADENOVIRUS
用 H5 010CMVHINF 腺病毒治疗复发性/进行性恶性神经胶质瘤
  • 批准号:
    6565876
  • 财政年份:
    2001
  • 资助金额:
    $ 22.84万
  • 项目类别:
TREATMENT OF RECURRENT/PROGRESSIVE MALIGNANT GLIOMA WITH H5 010CMVHINF ADENOVIRUS
用 H5 010CMVHINF 腺病毒治疗复发性/进行性恶性神经胶质瘤
  • 批准号:
    6468126
  • 财政年份:
    2000
  • 资助金额:
    $ 22.84万
  • 项目类别:
MECHANISMS OF ADENOVIRUS VACCINES FOR COLON CANCER
腺病毒疫苗治疗结肠癌的机制
  • 批准号:
    6300546
  • 财政年份:
    2000
  • 资助金额:
    $ 22.84万
  • 项目类别:
MECHANISMS OF ADENOVIRUS VACCINES FOR COLON CANCER
腺病毒疫苗治疗结肠癌的机制
  • 批准号:
    6103374
  • 财政年份:
    1999
  • 资助金额:
    $ 22.84万
  • 项目类别:
MECHANISMS OF ADENOVIRUS VACCINES FOR COLON CANCER
腺病毒疫苗治疗结肠癌的机制
  • 批准号:
    6269841
  • 财政年份:
    1998
  • 资助金额:
    $ 22.84万
  • 项目类别:
DEVELOPMENT, CHARACTERIZATION, AND PRODUCTION OF A B7 ADENOVIRUS VECTOR
B7 腺病毒载体的开发、表征和生产
  • 批准号:
    6103017
  • 财政年份:
    1997
  • 资助金额:
    $ 22.84万
  • 项目类别:
RECOMBINANT ADENOVIRUS VACCINE FOR COLON CANCER
结肠癌重组腺病毒疫苗
  • 批准号:
    2458280
  • 财政年份:
    1996
  • 资助金额:
    $ 22.84万
  • 项目类别:
RECOMBINANT ADENOVIRUS VACCINE FOR COLON CANCER
结肠癌重组腺病毒疫苗
  • 批准号:
    2010235
  • 财政年份:
    1996
  • 资助金额:
    $ 22.84万
  • 项目类别:

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cN1A肽主动免疫小鼠模型
  • 批准号:
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  • 批准号:
    8136035
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  • 财政年份:
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  • 财政年份:
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    $ 22.84万
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