Exercise & influenza immunity:Psychoneuroendocrine Model
锻炼
基本信息
- 批准号:6471076
- 负责人:
- 金额:$ 32.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-06-01 至 2005-05-31
- 项目状态:已结题
- 来源:
- 关键词:beta adrenergic receptor catecholamines cell proliferation clinical research cytokine cytotoxic T lymphocyte exercise helper T lymphocyte human old age (65+) human subject immunity immunization immunoglobulin G immunoregulation influenza inhibitor /antagonist neuroendocrine system psychological stressor
项目摘要
DESCRIPTION (provided by applicant): The purpose of the proposed study is to
investigate the effects of a regular, moderate exercise program on the immune
response to influenza immunization in older adults; and to determine whether
the mechanisms of the exercise-induced immunomodulation involve psychosocial
and/or neuroendocrine adaptations. Older adults experience a greater incidence
and severity of influenza infection, as well as reduced vaccine efficacy. We
hypothesize that exercise will enhance immune response to the vaccine and
improve psychosocial state. A total of 72 men and women > age 65 will be
assigned to an exercise (EX), n=36, or control (CON) group, n=36. An additional
32 subjects (n= 16 EX, n=16 CON) currently treated with non-selective
beta-adrenergic receptor antagonists will be recruited to test the hypothesis
that the immunomodulatory effects of exercise are mediated via catecholamine
activation of beta-adrenergic receptors. Subjects will be immunized with
influenza vaccine and will be randomly assigned to participate in either a
regular vigorous aerobic exercise program (EX) or a flexibility program (CON)
for one year. Blood samples will be taken pre and post-immunization. At the end
of one year, subjects will be immunized again and blood samples will be taken
pre-immunization and up to 6 months post-immunization. Psychosocial measures of
depression, perceived stress, social support, positive/negative affect, and
daily hassles/uplifts will be assessed numerous times throughout the study. The
primary immune outcome measures are: anti-influenza IgG and IgG1, influenza
specific peripheral blood mononuclear cell proliferation and cytokine
(interleukin (lL)-2, IL-10, interferon (IFN)-gamma) production, cytotoxic T
lymphocyte (CTL) function, and intracellular influenza-specific IL-2, IL-b 0,
IFN-gamma, in CD4+, CD8+, CD45RA+ and CD45RO+ cells. Growth curve modeling will
be used to analyze the relationship between treatment condition and changes in
the measures of immunocompetence over time. The findings from this study may
have relevance from both a clinical and basic research perspective, if moderate
exercise is associated with enhanced anti-influenza immunity and improved
protection from infection.
描述(由申请人提供):拟议研究的目的是
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marian L Kohut其他文献
Marian L Kohut的其他文献
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{{ truncateString('Marian L Kohut', 18)}}的其他基金
Adjuvant effect of physical exercise on immune response to COVID-19 vaccination and interactions with stress
体育锻炼对 COVID-19 疫苗接种免疫反应的辅助作用以及与压力的相互作用
- 批准号:
10593597 - 财政年份:2023
- 资助金额:
$ 32.33万 - 项目类别:
Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection
基于纳米疫苗的老年人流感病毒联合免疫:免疫与保护
- 批准号:
10211470 - 财政年份:2021
- 资助金额:
$ 32.33万 - 项目类别:
Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection
基于纳米疫苗的老年人流感病毒联合免疫:免疫与保护
- 批准号:
10353425 - 财政年份:2021
- 资助金额:
$ 32.33万 - 项目类别:
Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection
基于纳米疫苗的老年人流感病毒联合免疫:免疫与保护
- 批准号:
10553681 - 财政年份:2021
- 资助金额:
$ 32.33万 - 项目类别:
Exercise-induced immunomodulation in the aged: Mechanisms
老年人运动引起的免疫调节:机制
- 批准号:
8039182 - 财政年份:2007
- 资助金额:
$ 32.33万 - 项目类别:
Exercise-induced immunomodulation in the aged: Mechanisms
老年人运动引起的免疫调节:机制
- 批准号:
7778304 - 财政年份:2007
- 资助金额:
$ 32.33万 - 项目类别:
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