HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
批准号:
6489580
负责人:
CRAIG K HENKEL
金额:
$26.25万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-01-15 至 2005-12-31
中文摘要
描述:本应用程序将研究提升的发展
终止于下丘内的非重叠或
仅部分重叠的带状和斑块图案。传入带
终止代表了整个厚度的垂直偏析
下丘的纤维树突层和斑块代表
沿层平面的水平偏析。尚不清楚是否
这些模式是在传入纤维首先进入下层时建立的
丘或它们是否从最初的重叠中二次形成。
尽管如此,这些传入模式以及平行的纤维树突
下丘的结构,确定突触相互作用
发生在细胞核内。为了了解神经回路如何
涉及信息处理的发展,拟议的研究将确定
1)到达、分布和时空特征
传入预测的细化,2)这些事件与
突触发生和 3) 控制模式形成的机制
各层内的传入终止。具体来说,实验将
通过研究上升预测的发展来解决这些问题
从外侧上橄榄 (LSO) 和背侧到下丘
晚熟哺乳动物雪貂的外侧丘系核(DNLL)。的
LSO 和 DNLL 轴突向下投射的位置和分布
将在雪貂套件的正常发育系列中研究丘
耳蜗消融实验系列。亲脂性碳花青染料,
DiI 和 DiD,将用于标记同侧和对侧 LSO 和
DNLL 纤维的连合处。此外,突触的分布
沿着音调轴并平行于纤维树突层的接触
将在追踪确定的发育时间点采样
研究。了解对下等人的传入投射的发展
丘以及最终产生的集成电路对于
了解可能因遗传异常而面临风险的听觉功能,
营养不平衡、怀孕期间致畸剂的影响甚至可能
到早产。虽然随后的听觉体验可能会改变内在的
听觉回路,功能回路的初始构造仍然存在
理解神经和行为可塑性的基础,这可能会导致
合理干预和治疗结果。
英文摘要
DESCRIPTION: The present application will study development of ascending
projections that terminate within the inferior colliculus in non-overlapping or
only partially overlapping patterns of bands and patches. Bands of afferent
termination represent a vertical segregation across the thickness of the
fibrodendritic layers of the inferior colliculus and patches represent a
horizontal segregation along the plane of the layers. It is not known whether
these patterns are established as the afferent fibers first enter the inferior
colliculus or whether they form secondarily from an initial overlap.
Nevertheless these afferent patterns, together with the parallel fibrodendritic
architecture of the inferior colliculus, determine the synaptic interactions
that take place within the nucleus. In order to understand how neural circuits
involved in information processing develop, the proposed studies will identify
1) the spatial and temporal characteristics of arrival, distribution and
refinement of afferent projections, 2) the relationship of those events to
synaptogenesis and 3) the mechanisms that govern the formation of the pattern
of afferent termination within the layers. Specifically, experiments will
address these issues by studying the development of the ascending projections
to the inferior colliculus from the lateral superior olive (LSO) and dorsal
nucleus of the lateral lemniscus (DNLL) in an altricial mammal, the ferret. The
position and distribution of the LSO and DNLL axons projecting to the inferior
colliculus will be studied in a normal developmental series of ferret kits and
an experimental series with cochlear ablations. Lipophilic carbocyanine dyes,
DiI and DiD, will be used to label the ipsilateral and contralateral LSO and
the commissure of DNLL fibers. In addition, the distribution of synaptic
contacts along the tonotopic axis and parallel to the fibrodendritic layers
will be sampled at developmental time points determined from the tracing
studies. Knowledge of the development of afferent projections to the inferior
colliculus, and the integrative circuits that ultimately result, is critical in
understanding auditory functions that may be at risk due to genetic anomaly,
nutritional imbalance, effects of teratogens during pregnancy or perhaps even
to premature birth. While subsequent auditory experience may alter intrinsic
auditory circuits, the initial construction of functional circuits remains
fundamental to understanding neural and behavioral plasticity that may lead to
rational intervention and treatment outcomes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
-
批准号:6692165
-
项目类别:
-
资助金额:$29.48万
-
财政年份:2001
-
负责人:CRAIG K HENKEL
-
依托单位:
HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
-
批准号:6626887
-
项目类别:
-
资助金额:$29.48万
-
财政年份:2001
-
负责人:CRAIG K HENKEL
-
依托单位:
HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
-
批准号:6838825
-
项目类别:
-
资助金额:$29.48万
-
财政年份:2001
-
负责人:CRAIG K HENKEL
-
依托单位:
HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
-
批准号:6263252
-
项目类别:
-
资助金额:$31.08万
-
财政年份:2001
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURAL BASIS OF CENTRAL HEARING MECHANISMS
-
批准号:2126012
-
项目类别:
-
资助金额:$14.51万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURAL BASIS OF CENTRAL HEARING MECHANISMS
-
批准号:3217509
-
项目类别:
-
资助金额:$12.85万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMS
-
批准号:6175020
-
项目类别:
-
资助金额:$22.72万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURAL BASIS OF CENTRAL HEARING MECHANISMS
-
批准号:3217511
-
项目类别:
-
资助金额:$14.17万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMS
-
批准号:2900027
-
项目类别:
-
资助金额:$22.07万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMS
-
批准号:6379287
-
项目类别:
-
资助金额:$23.4万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMS
-
批准号:2612818
-
项目类别:
-
资助金额:$24.18万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURAL BASIS OF CENTRAL HEARING MECHANISMS
-
批准号:3217510
-
项目类别:
-
资助金额:$13.56万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMS
-
批准号:6516095
-
项目类别:
-
资助金额:$24.1万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURAL BASIS OF CENTRAL HEARING MECHANISMS
-
批准号:2126010
-
项目类别:
-
资助金额:$13.68万
-
财政年份:1990
-
负责人:CRAIG K HENKEL
-
依托单位:
ORGANIZATION OF AUDITORY-MOTOR PATHWAYS IN THE MIDBRAIN
-
批准号:3398639
-
项目类别:
-
资助金额:$7.22万
-
财政年份:1982
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURAL BASIS FOR AUDITORY PROCESSING LATERAL LEMNISCUS; BIOCYTIN; AVIDIN;
-
批准号:3868510
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:CRAIG K HENKEL
-
依托单位:
STRUCTURAL BASIS FOR AUDITORY PROCESSING
-
批准号:3889898
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:CRAIG K HENKEL
-
依托单位:
海外基金