How microbes build their environments through evolutionary feedback

微生物如何通过进化反馈构建它们的环境

• 批准号: FT140100398
• 负责人: Prof Mark Tanaka
• 金额: $ 55.02万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-10-18
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100398
• 关键词: How; microbes; build; their; environments

The fitness landscape, a key evolutionary concept, relates genes or traits to reproductive fitness. However, this has been challenged by organisms that distort the landscape by changing their environments. This project aims to develop a new mathematical model that restores the landscape concept by extending it to accommodate niche construction. This framework will be applied to microorganisms that alter their environments, for example, by provoking and subverting the host immune system, and by inducing behavioural change in hosts. These processes alter how natural selection operates on microbes and thus lead to important evolutionary feedback. The model will be used to examine antibiotic resistance, pathogen virulence and how microbiomes develop.

适合度是一个关键的进化概念，它将基因或特征与生殖适合度联系起来。然而，这一点受到了通过改变环境来扭曲景观的有机体的挑战。该项目旨在开发一种新的数学模型，通过扩展景观概念来适应利基结构，从而恢复景观概念。这一框架将应用于改变其环境的微生物，例如，通过激发和颠覆宿主免疫系统，以及通过诱导宿主行为改变。这些过程改变了自然选择对微生物的作用方式，从而产生了重要的进化反馈。该模型将用于检查抗生素耐药性、病原体毒力以及微生物群如何发展。