Mathematical models and bioinformatic analyses of bacterial genome evolution

细菌基因组进化的数学模型和生物信息学分析

• 批准号: DP0987302
• 负责人: Prof Mark Tanaka
• 金额: $ 44.02万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0987302
• 关键词: Mathematical; models; bioinformatic; analyses; bacterial

Bacteria are vital agents in earth's biosphere, breaking down and synthesising a wide variety of compounds. Some bacteria cause disease; others are exploited for a range of biotechnological applications. Bacteria have a remarkable ability to survive and thrive in changing conditions. For example, pathogenic bacteria confronted by antibiotics easily evolve resistance to them. With the reality of climate change, we expect more rapid shifts in the structure of bacterial communities, possibly leading to the emergence of new pathogens. The benefits of this project are to discover how the genetic structure of bacteria confer this flexibility, and to help keep Australia at the forefront of research in bioinformatics and mathematical biology.

细菌是地球生物圈中的重要媒介，分解和合成各种化合物。有些细菌会导致疾病，有些则被用于一系列生物技术应用。细菌具有在不断变化的条件下生存和繁衍的非凡能力。例如，面对抗生素的病原菌很容易对它们产生耐药性。随着气候变化的现实，我们预计细菌群落的结构将发生更快的变化，可能导致新病原体的出现。该项目的好处是发现细菌的遗传结构如何赋予这种灵活性，并帮助澳大利亚保持在生物信息学和数学生物学研究的前沿。