Recovering the damaged brain after haemorrhagic stroke

恢复出血性中风后受损的大脑

基本信息

  • 批准号:
    1923903
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Studentship
  • 财政年份:
    2017
  • 资助国家:
    英国
  • 起止时间:
    2017 至 无数据
  • 项目状态:
    已结题

项目摘要

Approximately 152,000 strokes occur each year in the UK and one every two seconds worldwide (1). Half of all stroke survivors are left with a disability. Compared to ischaemic stroke, haemorrhagic stroke is associated with high mortality, greater disability and post-stroke co-morbidity, but is currently understudied. Furthermore there is no treatment for haemorrhagic stroke that results in full neuronal recovery due to the brain's poor self-renewing ability (2). Brain regeneration approaches focus greatly on neural stem cell (NSC) transplantation to replace the damaged tissue. However, limitations that hamper the development of a successful stem cell therapy include, poor survival and reduced interaction and integration of the transplanted cells with the surrounding tissue (3, 4). Even if functional integration is facilitated, absence of appropriate architecture hinders the formation of reciprocal connections between the transplanted cells and host (5). A possible solution to these limitations is the development of a hydrogel to promote survival and growth of the transplanted cells and to provide precise spatial cues for neuronal differentiation within the haematoma/perihaematoma after intracerebral haemorrhage (ICH). This project combines 3D cell culture, biomaterial, stem cell and neuroscience expertise for the development of a successful stem cell therapy for ICH.
英国每年约有152,000例中风,全世界每两秒钟就有一例(1)。一半的中风幸存者留下残疾。与缺血性卒中相比,出血性卒中与高死亡率、更大残疾和卒中后合并症相关,但目前研究不足。此外,由于大脑自我更新能力差,出血性中风没有导致神经元完全恢复的治疗方法(2)。神经干细胞移植是脑再生研究的热点。然而,阻碍成功的干细胞疗法的发展的限制包括,存活率差和移植细胞与周围组织的相互作用和整合减少(3,4)。即使促进了功能整合,缺乏适当的结构也会阻碍移植细胞和宿主之间形成相互连接(5)。这些限制的一个可能的解决方案是开发一种水凝胶,以促进移植细胞的存活和生长,并为脑出血(ICH)后血肿/血肿周围的神经元分化提供精确的空间线索。该项目结合了3D细胞培养,生物材料,干细胞和神经科学专业知识,为ICH开发成功的干细胞治疗。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

其他文献

Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
  • DOI:
    10.1002/cam4.5377
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    4
  • 作者:
  • 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
  • DOI:
    10.1186/s12889-023-15027-w
  • 发表时间:
    2023-03-23
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
  • 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
  • DOI:
    10.1007/s10067-023-06584-x
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
  • 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
  • DOI:
    10.1186/s12859-023-05245-9
  • 发表时间:
    2023-03-26
  • 期刊:
  • 影响因子:
    3
  • 作者:
  • 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
  • DOI:
    10.1039/d2nh00424k
  • 发表时间:
    2023-03-27
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
  • 通讯作者:

的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('', 18)}}的其他基金

An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    --
  • 项目类别:
    Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
  • 批准号:
    2896097
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
  • 批准号:
    2780268
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
  • 批准号:
    2908918
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
  • 批准号:
    2908693
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
  • 批准号:
    2890513
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
  • 批准号:
    2879865
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
  • 批准号:
    2876993
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship

相似海外基金

The neural basis of Japanese language based on brain damaged patients - From individual differences to personalized medicine
基于脑损伤患者的日语神经基础——从个体差异到个性化医疗
  • 批准号:
    21H03779
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Functional regeneration program for the damaged brain with hemispatial apraxia using the stereoscopic sensory stimulation and transcranial alternating current stimulation.
使用立体感觉刺激和经颅交流电刺激对患有半侧空间失用症的受损大脑进行功能再生计划。
  • 批准号:
    17K01527
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Comprehensive study on assessment and intervention for pragmatic communication disorders in brain damaged patients
脑损伤患者语用沟通障碍评估与干预综合研究
  • 批准号:
    15K08562
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Engineering biochemically active soft materials to promote regeneration of damaged brain and spinal cord tissue
工程生化活性软材料促进受损大脑和脊髓组织的再生
  • 批准号:
    454427-2014
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Engineering biochemically active soft materials to promote regeneration of damaged brain and spinal cord tissue
工程生化活性软材料促进受损大脑和脊髓组织的再生
  • 批准号:
    454427-2014
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Developing an Adaptive Cognitive Prosthetic to Replace Damaged Brain Regions
开发自适应认知假体来替代受损的大脑区域
  • 批准号:
    8755948
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Study on the improvements of the damaged brain networks in refractory depression.
难治性抑郁症受损脑网络改善的研究。
  • 批准号:
    26461723
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Cell therapy by human iPSC-transplantation for functional repair of stroke-damaged neural circuitry and malignant brain tumor
通过人类 iPSC 移植进行细胞疗法,用于修复中风损伤的神经回路和恶性脑肿瘤的功能
  • 批准号:
    26462171
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Syntactic, phonological and semantic influence on sentence production/comprehension in brain damaged and normal people
句法、语音和语义对脑损伤者和正常人句子产生/理解的影响
  • 批准号:
    26370493
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
增强受损脊髓的可塑性以修复传输和功能
  • 批准号:
    8668722
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了